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ZHAO, Haoyu

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Operationalizing outpatient palliative care referral criteria in lung cancer patients - a population-based cohort study using health administrative data

IQBAL, Javaid ; SUTRADHAR, Rinku ; ZHAO, Haoyu ; HOWELL, Doris ; O'BRIEN, Mary Ann ; SEOW, Hsien ; DUDGEON, Deborah J. ; ATZEMA, Clare ; EARLE, Craig C. ; DEANGELIS, Carlo ; SUSSMAN, Jonathan ; BARBERA, Lisa
JOURNAL OF PALLIATIVE MEDICINE, 05/2020, vol.23, n°5, p. 670-677

Thème : Santé. Cote : 00.07JOU

HOSPITALISATION JOUR ; ETUDE COHORTE ; RECHERCHE ; SERVICE HOSPITALIER ; CANCER RESPIRATOIRE ; POUMON ; OBSERVATION ; DEMARCHE PALLIATIVE ; CANADA

Background: Early referral of cancer patients for palliative care significantly improves the quality of life. It is not clear which patients can benefit from an early referral, and when the referral should occur. A Delphi Panel study proposed 11 major criteria for an outpatient palliative care referral.
Objective: To operationalize major Delphi criteria in a cohort of lung cancer patients, using a prospective approach, by linking health administrative data.
Design: Population-based observational cohort study.
Setting/Subjects: The study population comprised 38,851 cases of lung cancer in the Ontario Cancer Registry, diagnosed from January 1, 2012, to December 31, 2016.
Measurements: We operationalized 6 of the 11 major criteria (4 diagnosis or prognosis based and 2 symptom based). Patients were considered eligible (index event) for palliative care if they qualified for any criterion. Among eligible patients, we identified those who received palliative care.
Results: Twenty-eight thousand one hundred sixty-four patients were eligible for palliative care by qualifying for either the diagnosis- or prognosis-based criteria (n = 21,036, 76.5%), or for symptom-based criteria (n = 7128, 23.5%). A total of 23,199 (82.4%) patients received palliative care. The median time from palliative care eligibility to the receipt of first palliative care or death or maximum study follow-up was 56 days (range = 17–348).
Conclusions: We operationalized six major criteria that identified the majority of lung cancer patients who were eligible for palliative care. Most eligible patients received the palliative care before death. Future research is warranted to test these criteria in other cancer populations.

Patient-reported symptoms following diagnosis in esophagus cancer patients treated with palliative intent

DAVIS, Laura E. ; GUPTA, Vaibhav ; ALLEN-AYODABO, Catherine ; ZHAO, Haoyu ; HALLET, Julie ; MAHAR, Alyson L. ; RINGASH, Jolie ; DOHERTY, Mark ; KIDANE, Biniam ; DARLING, Gail ; COBURN, Natalie G.
Diseases of the esophagus, 20/01/2020, Pagination inconnue

Document en ligne

Thème : Médecine.

CANCER OTO RHINO LARYNGOLOGIQUE ; ETUDE COHORTE ; SYMPTOME ; ETUDE RETROSPECTIVE ; QUALITE VIE ; PHASE PALLIATIVE

The majority of patients with esophagus cancer have advanced-stage disease without curative options. For these patients, treatment is focused on improving symptoms and quality of life. Despite this, little work has been done to quantify symptom burden for incurable patients. We describe symptoms using the Edmonton Symptom Assessment System (ESAS) among esophagus cancer patients treated for incurable disease. This retrospective cohort study linked administrative datasets to prospectively collected ESAS data of non-curatively treated adult esophagus cancer patients diagnosed between January 1, 2009 and September 30, 2016. ESAS measures nine common cancer-related symptoms: anxiety, depression, drowsiness, lack of appetite, nausea, pain, shortness of breath, tiredness, and impaired well-being. Frequency of severe symptoms (score = 7/10) was described by month for the 6 months from diagnosis for all patients and by treatment type (chemotherapy alone, radiotherapy alone, both chemotherapy and radiotherapy, and best supportive care). A sensitivity analysis limited to patients who survived at least 6 months was performed to assess robustness of the results to proximity to death and resulting variation in follow-up time. Among 2,989 esophagus cancer patients diagnosed during the study period and meeting inclusion criteria, 2,103 reported at least one ESAS assessment in the 6 months following diagnosis and comprised the final cohort. Patients reported a median of three (IQR 2–7) ESAS assessments in the study period. Median survival was 7.6 (IQR 4.1–13.7) months. Severe lack of appetite (53.1%), tiredness (51.1%), and impaired well-being (42.7%) were the most commonly reported symptoms. Severe symptoms persisted throughout the 6 months after the diagnosis. Subgroup analysis by treatment showed no worsening of symptoms over time in those treated by either chemotherapy alone, or both chemotherapy and radiation. Results followed a similar pattern on sensitivity analysis. Patients diagnosed with incurable esophagus cancer experience considerable symptom burden in the first 6 months after diagnosis and the frequency of severe symptoms remains high throughout this period. Patients with this disease require early palliative care and psychosocial support upon diagnosis and support throughout the course of their cancer journey.

Origine : PubMed

Symptom burden at the end of life for neuroendocrine tumors - an analysis of 2579 prospectively collected patient-reported outcomes

HALLET, Julie ; DAVIS, Laura E. ; MAHAR, Alyson L. ; ISENBERG-GRZEDA, Elie ; BUBIS, Lev D. ; MYREHAUG, Sten ; ZHAO, Haoyu ; BEYFUSS, Kaitlyn ; MOODY, Lesley ; LAW, Calvin H. L. ; COBURN, Natalie G.
Annals of surgical oncology, 09/2019, vol.26, n°9, p. 2711-2721

Document en ligne

Thème : Médecine.

SYMPTOME ; FIN VIE ; NEUROLOGIE ; ETUDE COHORTE ; ETUDE RETROSPECTIVE ; CANADA

Background: Given a slow course of disease, end-of-life issues are understudied in neuroendocrine tumors (NETs). To date, there are no data regarding symptoms at the end of life. This study examined symptom trajectories and factors associated with high symptom burden in NETs at the end of life.
Methods: We conducted a retrospective cohort study of NET patients diagnosed from 2004 to 2015 and who died between 2007 and 2016, in Ontario, Canada. Prospectively collected patient-reported Edmonton Symptom Assessment System scores were linked to administrative healthcare datasets. Moderate-to-severe symptom scores (= 4 out of 10) in the 6 months before death were analyzed, with multivariable modified Poisson regression identifying factors associated with moderate-to-severe symptoms scores.
Results: Among 677 NET decedents, 2579 symptom assessments were recorded. Overall, moderate-to-severe scores were most common for tiredness (86%), wellbeing (81%), lack of appetite (75%), and drowsiness (68%), with these proportions increasing as death approached. For symptoms of lack of appetite, drowsiness, and shortness of breath, the increase was steepest in the 8 weeks before death. On multivariable analyses, the risk of moderate-to-severe symptoms was significantly higher in the last 2 months before death and for patients with shorter survival (< 6 months). Women had higher risks of anxiety, nausea, and pain.
Conclusion: A high prevalence of moderate-to-severe symptoms was observed for NETs at the end of life, not previously described. The proportion of moderate-to-severe symptoms increases steeply as death nears, highlighting an opportunity for improved management. Combined with identified factors associated with moderate-to-severe symptoms, this information is important to improve patient-centred and personalized supportive care for NETs at the end of life.

Origine : PubMed

Symptom trajectories and predictors of severe symptoms in pancreatic adenocarcinoma at the end-of-life - a population based analysis of 2,538 patients

HAMMAD, Ahmed ; DAVIS, Laura E. ; MAHAR, Alyson L. ; BUBIS, Lev D. ; ZHAO, Haoyu ; EARLE, Craig C. ; BARBERA, Lisa ; HALLET, Julie ; COBURN, Natalie G.
HPB: the official journal of the International Hepato Pancreato Biliary Association, 09/07/2019, Pagination inconnue

Document en ligne

Thème : Médecine.

CANCER DIGESTIF ; FIN VIE ; SYMPTOME ; ETUDE COHORTE ; ETUDE RETROSPECTIVE ; TRAJECTOIRE MALADIE ; EVALUATION ; ECHELLE MESURE

Background: We evaluated symptom trajectories and predictors of reporting severe symptoms in the last 6 months of life among non-resected pancreatic adenocarcinoma (PAC) decedents.
Methods: A retrospective cohort study of non-resected PAC decedents receiving care at regional cancer centres between January 2007 and December 2015. Symptoms were measured using the Edmonton Symptom Assessment System (ESAS). We described the proportion of patients reporting severe (score =7) symptoms by 2-week intervals during the six months prior to death. Multivariable modified Poisson regression models identified predictors of reporting severe symptom scores in the last 6 months of life.
Results: 2538 non-resected PAC decedents treated at regional cancer centres had =1 symptom ESAS record in the last six months of life, totaling 10,893 unique symptom assessments. Tiredness was the most commonly reported symptom (59% reporting =1 severe score), followed by lack of appetite (57%), impaired-wellbeing (49%) and drowsiness (42%). All symptoms increased closer to death. Older age, female sex, higher comorbidity status, survival less than 6 months, and urban residence were associated with a significantly higher risk of reporting severe symptoms.
Conclusion: Non-resected PAC patients experience significant symptom burden nearing death. Patient subsets may benefit from personalized supportive care interventions.

Origine : PubMed

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CANADA CANCER DIGESTIF CANCER OTO RHINO LARYNGOLOGIQUE CANCER RESPIRATOIRE DEMARCHE PALLIATIVE ECHELLE MESURE ETUDE COHORTE ETUDE RETROSPECTIVE EVALUATION FIN VIE HOSPITALISATION JOUR NEUROLOGIE OBSERVATION PHASE PALLIATIVE SYMPTOME

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