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Variability of cost trajectories over the last year of life in patients with advanced breast cancer in the Netherlands

SCHNEIDER, Paul P. ; POUWELS, Xavier G. L. V. ; PASSOS, Valéria Lima ; RAMAEKERS, Bram L. T. ; GEURTS, Sandra M. E. ; IBRAGIMOVA, Khava I. E. ; DE BOER, Maaike ; ERDKAMP, Frans ; VRIENS, Birgit E. P. J. ; VAN DE WOUW, Agnes J. ; DEN BOER, Marien O. ; PEPELS, Manon J. ; TJAN-HEIJNEN, Vivianne C. G. ; JOORE, Manuela A.
Plos one, 09/04/2020, vol.15, n°4, p. 1-14

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The impact of granulocyte colony-stimulating factor use in patients with metastatic breast cancer treated with palliative chemotherapy - a single-institution retrospective review

MOUSA, Luay ; STEPHENS, Julie A. ; BERGER, Michael ; RAMASWAMY, Bhuvaneswari ; LUSTBERG, Maryam ; SARDESAI, Sagar ; WILLIAMS, Nicole ; VANDEUSEN, Jeffrey ; STOVER, Daniel ; CHERIAN, Mathew ; MORGAN, Evan ; WESOLOWSKI, Robert
Supportive care in cancer, 17/03/2020, Pagination inconnue

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A phase II study of pembrolizumab in combination with palliative radiotherapy for hormone receptor-positive metastatic breast cancer

BARROSO-SOUSA, Romualdo ; KROP, Ian E. ; TRIPPA, Lorenzo ; TAN-WASIELEWSKI, Zhenying ; LI, Tianyu ; OSMANI, Wafa ; ANDREWS, Chelsea ; DILLON, Deborah ; RICHARDSON, Edward T. ; PASTORELLO, Ricardo G. ; WINER, Eric P. ; MITTENDORF, Elizabeth A. ; BELLON, Jennifer R. ; SCHOENFELD, Jonathan D. ; TOLANEY, Sara M.
Clinical breast cancer, 30/01/2020, Pagination inconnue

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Caregiving motivations and experiences among family caregivers of patients living with advanced breast cancer in Ghana

KUSI, Grace ; BOAMAH MENSAH, Adwoa Bemah ; BOAMAH MENSAH, Kofi ; DZOMEKU, Veronica Millicent ; APIRIBU, Felix ; DUODU, Precious Adade
Plos one, 2020, vol.15, n°3, p. 1-17

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"I'd want to know, because a year's not a long time to prepare for a death" - role of prognostic information in shared decision making among women with metastatic breast cancer

NIRANJAN, Soumya J. ; TURKMAN, Yasemin ; WILLIAMS, Beverly R. ; WILLIAMS, Courtney P. ; HALILOVA, Karina I. ; SMITH, Tom ; KNIGHT, Sara J. ; BHATIA, Smita ; ROCQUE, Gabrielle B.
JOURNAL OF PALLIATIVE MEDICINE, 11/02/2020, Pagination inconnue

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Palliative care - not only for treating symptoms: a case report

PALLOTTI, Maria Caterina ; RICCI, Marianna ; ROSSI, Romina ; CECCONETTO, Lorenzo ; BARONE, Domenico ; MALTONI, Marco
Tumori, 03/02/2020, Pagination inconnue

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Factors affecting decisions regarding terminal care locations of patients with metastatic breast cancer

NOGAMI, Noriko ; NAKAI, Katsuya ; HORIMOTO, Yoshiya ; MIZUSHIMA, Akio ; SAITO, Mitsue
The American journal of hospice and palliative care, 23/01/2020, Pagination inconnue

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Comparative effectiveness of palliative chemotherapy in metastatic breast cancer - a real-world evidence analysis

FEINBERG, Bruce ; KISH, Jonathan ; DOKUBO, Igoni ; WOJTYNEK, Jeff ; GAJRA, Ajeet ; LORD, Kevin
The oncologist, 17/01/2020, p. 1-8

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Thème : Médecine. Cote : eD03.05.01

CHIMIOTHERAPIE ; CANCER SEIN ; EFFICACITE

BACKGROUND: In the absence of randomized controlled trials, real-world evidence may aid practitioners in optimizing the selection of therapy for patients with cancer. The study's aim was to determine real-word use, as well as compare effectiveness, of single-agent and combination chemotherapy as palliative treatment for female patients with metastatic breast cancer (mBC).
MATERIALS AND METHODS: Using administrative claims data from the Symphony Health's Integrated Oncology Dataverse, female patients with mBC treated with at least one chemotherapy-only treatment (COT) between January 1, 2013, and December 31, 2017 were selected. The frequency of use of single-agent versus combination chemotherapy overall and by line of therapy (LOT) was calculated whereas effectiveness was measured using time to next treatment (TNT).
RESULTS: A total of 12,381 patients with mBC were identified, and 3,777 (31%) received at least one line of COT. Of the 5,586 observed LOTs among the 3,777 patients, 66.5% were single-agent and 33.5% combination chemotherapy. Combination chemotherapy was most frequently used in first-line (45%) and least frequently in fifth-line (16%). Across all LOTs, median TNT was significantly longer for single-agent versus combination chemotherapy (5.3 months vs. 4.1 months, p < .0001). Comparison of median TNT by LOT showed significance in third-line and greater but not in first-line or second-line. Among single agents, the median TNT for patients receiving capecitabine was longest in comparison to all other single agents.
CONCLUSIONS: The frequency of combination COT use, particularly in first-line, warrants further research given published guideline recommendations. The observed TNT difference favoring single-agent treatment in later lines supports guideline recommendations. Variance between single-agent preference and observed TNT was noteworthy.
IMPLICATIONS FOR PRACTICE: Although published data from evidence- and consensus-based guidelines recommend single-agent over combination chemotherapy, the extensive list of agents available for use and a gap in the comparative effectiveness research of these agents have resulted in significant variances in patterns of care. The aim of this study was to assess real-world treatment patterns and their effectiveness during palliative therapy of metastatic breast cancer. The objective was to understand when and how chemotherapy-only treatment is used in metastatic breast cancer and whether comparative effectiveness analysis supports the observed patterns of care.

Origine : PubMed

Addressing child custody concerns of parents with life-limiting illness

NELSON, Courtney A. ; STANTON, Kate E. ; BOWERS, Savannah M. ; PARK, Eliza M.
JOURNAL OF PALLIATIVE MEDICINE, 09/12/2019, Pagination inconnue

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Do longitudinally-collected symptom scores predict time to death in advanced breast cancer - a joint modelling analysis

BUDHWANI, Suman ; MOINEDDIN, Rahim ; WODCHIS, Walter P. ; ZIMMERMANN, Camilla ; HOWELL, Doris
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 05/2020, vol.59, n°5, p. 1009-1018

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Natural language processing to assess palliative care and end-of-life process measures in patients with breast cancer with leptomeningeal disease

BRIZZI, Kate ; ZUPANC, Sophia N. ; UDELSMAN, Brooks V. ; TULSKY, James A. ; WRIGHT, Alexi A. ; POORT, Hanneke ; LINDVALL, Charlotta
The American journal of hospice and palliative care, 05/2020, vol.37, n°5, p. 371-376

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Four conversations - a randomized controlled trial of an online, personalized coping, and decision aid for metastatic breast cancer patients

SMITH, Sophia K. ; WESTBROOK, Kelly ; MACDERMOTT, Kristin ; AMARASEKARA, Sarthya ; LEBLANC, Matthew ; PAN, Wei
JOURNAL OF PALLIATIVE MEDICINE, 22/10/2019, p. 1-6

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From palliative to curative intent - PET/CT findings in the light of breast cancer intrinsic subgroup

BRUNET, Maxime ; CAZEAU, Anne-Laure ; BEN REJEB, Houda ; CATENA, Vittorio ; GRELLETY, Thomas
Tumori, 23/10/2019, Pagination inconnue

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Outcome and feasibility of palliative chemotherapy in very elderly patients with metastatic breast cancer

OVERGAAUW, Audrey J. C. ; SPEIJERS-VAN DER PLAS, Linda M. ; HENDRIKS, Mathijs P. ; SMORENBURG, Carolien H.
The breast journal, 20/09/2019, Pagination inconnue

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Vivre avec la maladie grave

MASSE-ZION, Karine
ASP LIAISONS, 06/2019, n°58, p. 27-29

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Symptom palliation of hypofractionated radiotherapy for patients with incurable inflammatory breast cancer

CHOI, Hoon Sik ; JANG, Hong Seok ; KANG, Ki Mun ; CHOI, Byung-Ock
Radiation oncology, 20/06/2019, vol.14, n°1, 6 p.

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Dexmedetomidine as an option for opioid refractory pain in the hospice setting

MUPAMOMBE, Charles T. ; LUCZKIEWICZ, Debra ; KERR, Christopher
JOURNAL OF PALLIATIVE MEDICINE, 13/06/2019, Pagination inconnue

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The support, education, and advocacy (SEA) program of care for women with metastatic breast cancer - a nurse-led palliative care demonstration program

REISER, Victoria ; ROSENZWEIG, Margaret ; WELSH, Ann ; REN, Dianxu ; USHER, Barbara
The American journal of hospice and palliative care, 10/2019, vol.36, n°10, p. 864-870

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Psycho-oncology care in breast cancer centres - a nationwide survey

ERNSTMANN, Nicole ; ENDERS, Anna ; HALBACH, Sarah ; NAKATA, Hannah ; KEHRER, Christina ; PFAFF, Holger ; GEISER, Franziska
BMJ supportive and palliative care, 13/04/2019, 4 p.

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The meaning of spirituality and spiritual well-being among Thai breast cancer patients - a qualitative study

PHENWAN, Tharin ; PEERAWONG, Thanarpan ; TULATHAMKIJ, Kandawsri
Indian journal of palliative care, 03/2019, vol.25, n°1, p. 119-123

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