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Recurrent cervical cancer treated with palliative chemotherapy - real-world outcome

MAILANKODY, Sharada ; DHANUSHKODI, Manikandan ; GANESAN, Trivadi S ; RADHAKRISHNAN, Venkatraman ; CHRISTOPHER, Vasanth ; GANESHARAJAH, Selvaluxmy ; SAGAR, Tenali Gnana
Ecancermedicalscience, 13/10/2020, vol.14, p. 1-10

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Thème : Médecine. Cote : eD03.05.01

CANCER GENITAL ; CHIMIOTHERAPIE ; INDE ; ETUDE RETROSPECTIVE

Introduction: Cervical cancer is the third most common cancer in India. There is limited data on the treatment of relapsed cervical cancer from India; therefore, we report the outcomes of patients with recurrent cervical cancer who were treated with palliative chemotherapy (CT).
Materials and methods: This was a retrospective study of patients with recurrent cervical cancer who received palliative CT from January 2012 to December 2016. The demographic details, clinical profile and survival outcomes were collected. Patients were treated with carboplatin or paclitaxel and carboplatin. Local radiation was given for symptomatic patients. Patients were assessed for responses clinically and/or radiologically after three and six cycles of CT. Progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan–Meier method.
Results: Forty-six patients with recurrent cervical cancer were included in this analysis, with a median follow-up of 9.4 months. The median age was 49.5 (25–65) years and the median disease-free interval was 31.3 (2–196) months. Biopsy confirmation of relapse was established in 63%. The median number of CT cycles was six. Twenty-four (52.2%) patients completed six cycles of CT. The overall response rate was 56.5%. Patients with a complete or a partial response were more likely to have PFS > 6 months (p < 0.0001). Median PFS and OS were, respectively, 8.4 (95% CI 6.1–10.7) months and 10.3 (95% CI 6.8–13.8) months. The completion of all cycles of CT and the site of metastasis (nodal vs. visceral or combined) were found to be associated with OS.
Conclusion: Palliative CT with paclitaxel carboplatin is a safe and effective option in Indian patients with recurrent cervical cancer, with more than half of the patients completing the prescribed CT. Further prospective trials may be required to place this treatment in the right context, in this era of immunotherapy and targeted therapy. However, knowing the outcomes in our population and prognostic factors will help in better prognostication of patients, thereby channelling our limited resources where necessary.

Origine : PubMed Central

Early-onset pancreatic cancer - an institutional series evaluating end-of-life care

KADAKIA, Kunal C. ; TRUFAN, Sally J. ; JAGOSKY, Megan H. ; WORRILOW, William M. ; HARRISON, Bradley W. ; BROYHILL, Katherine L. ; HWANG, Jimmy J. ; MUSSELWHITE, Laura W. ; AKTAS, Aynur ; WALSH, Declan ; SALEM, Mohamed E.
Supportive care in cancer, 10/11/2020, Pagination inconnue

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How do claims-based measures of end-of-life care compare to family ratings of care quality?

CHRISTIAN, Thomas J. ; HASSOL, Andrea ; BROOKS, Gabriel A. ; GU, Qian ; KIM, Seyoun ; LANDRUM, Mary Beth ; KEATING, Nancy L.
Journal of the American Geriatrics Society, 09/11/2020, Pagination inconnue

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Identification of factors associated with aggressive end-of-life antitumour treatment - retrospective study of 1282 patients with cancer

DEBOURDEAU, Philippe ; BELKACEMI, Mohamed ; ECONOMOS, Guillaume ; ASSÉNAT, Eric ; HILGERS, Werner ; COUSSIROU, Julie ; UZAN, Sfaya Kouidri ; VASQUEZ, Léa ; DEBOURDEAU, Antoine ; DAURES, Jean Pierre ; SALAS, Sebastien
BMJ supportive and palliative care, 05/11/2020, Pagination inconnue

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Symptom evolution in patients with esophageal and gastric cancer receiving palliative chemotherapy - a population-based study

MERCHANT, Shaila J. ; KONG, Weidong ; BRUNDAGE, Michael ; BOOTH, Christopher M.
Annals of surgical oncology, 02/11/2020, Pagination inconnue

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Analysis of prognostic factors and design of prognosis model for patients with stage IV gastric cancer following first-line palliative chemotherapy

ZHOU, Qiyin ; LAN, Xi ; LI, Ni ; YUAN, Daozu ; ZHANG, Jiliang
Cancer management and research, 2020, vol.12, p. 10461-10468

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Chemotherapy in the last 30 days and 14 days of life in African Americans with lung cancer

JOHNSON, Lee Ann ; ELLIS, Charles
The American journal of hospice and palliative care, 28/10/2020, Pagination inconnue

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Too much too late? - chemotherapy administration at the end of life: a retrospective observational study

WILKERSON, David H. ; SANTOS, Jennifer L. ; TAN, Xiyan ; GOMEZ, Teny Henry
The American journal of hospice and palliative care, 28/10/2020, Pagination inconnue

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Chemotherapy use and quality of life in cancer patients at the end of life - an integrative review

AKHLAGHI, Elham ; LEHTO, Rebecca H. ; TORABIKHAH, Mohsen ; SHARIF NIA, Hamid ; TAHERI, Ahmad ; ZABOLI, Ehsan ; YAGHOOBZADEH, Ameneh
Health and quality of life outcomes, 2020, vol.18, n°1, p. 1-9

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One last round of chemo? - insights from conversations between oncologists and lung cancer patients about prognosis and treatment decisions

HAUGE, Amalie M.
Social science and medicine, 04/10/2020, vol.266, Pagination inconnue

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Real world evidence on second-line palliative chemotherapy in advanced pancreatic cancer

GRANSMARK, Emma ; BAGENHOLM BYLIN, Nellie ; BLOMSTRAND, Hakon ; FREDRIKSON, Mats ; AVALL-LUNDQVIST, Elisabeth ; ELANDER, Nils O.
Frontiers in oncology, 2020, vol.10, Ill.

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Effect of delayed palliative chemotherapy on survival of patients with recurrent ovarian cancer

PYEON, Seung Yeon ; HAN, Gwan Hee ; KI, Kyung Do ; LEE, Kwang-Beom ; LEE, Jong-Min
Plos one, 23/07/2020, vol.15, n°7, p. 1-8

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A cohort study and meta-analysis of the evidence for consideration of Lauren subtype when prescribing adjuvant or palliative chemotherapy for gastric cancer

WANG, Kunning ; LI, Enxiao ; BUSUTTIL, Rita A. ; KONG, Joseph C. ; PATTISON, Sharon ; SUNG, Joseph J. Y. ; YU, Jun ; EL-OMAR, Emad M. ; SIMPSON, Julie A. ; BOUSSIOUTAS, Alex
Therapeutic advances in medical oncology, 2020, vol.12, p. 1-22

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Factors associated with the initiation of chemotherapy within 90 days of death in metastatic colorectal cancer patients - a population-based study

BATRA, Atul ; MCKINNON, Geoff ; BILLAWALA, Alkarim ; SHEKA, Dropen ; KONG, Shiying ; CHEUNG, Winson Y.
Supportive care in cancer, 29/07/2020, Pagination inconnue

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Clinical evaluation of plasma coagulation parameters in patients with advanced-stage non-small cell lung cancer treated with palliative chemotherapy in China

ABBAS, Muhammad ; KASSIM, Said Abasse ; WANG, Zhong-Chang ; SHI, Meiqi ; HU, Yiqiao ; ZHU, Hai-Liang
International journal of clinical practice, 29/07/2020, p. 1-13

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Use of palliative chemotherapy near the end of life - a retrospective cohort study

ZHANG, Zhe ; CHEN, Meng-Lei ; GU, Xiao-Li ; CHENG, Wen-Wu
Annals of palliative medicine, 31/07/2020, p. 1-8

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Chemotherapy at the end of life

URVAY, Semiha ; CIVELEK, Burak ; ÖZASLAN, Ersin ; SÜREL, Aziz Ahmet
JOURNAL OF PALLIATIVE CARE, 06/08/2020, Pagination inconnue

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The effect of disclosing life expectancy information on patients' prognostic understanding - secondary outcomes from a multicenter randomized trial of a palliative chemotherapy educational intervention

ENZINGER, Andrea ; UNO, Hajime ; MCCLEARY, Nadine ; FRANK, Elizabeth ; SANOFF, Hanna ; VAN LOON, Katherine ; MATIN, Khalid ; BULLOCK, Andrea ; CRONIN, Christine ; BAGLEY, Janet ; SCHRAG, Deborah
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 07/08/2020, p. 1-14

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Utility of the modified frailty index in predicting toxicity and cancer outcomes for older adults with advanced pancreatic cancer receiving first-line palliative chemotherapy

RITTBERG, Rebekah ; ZHANG, Hanbo ; LAMBERT, Pascal ; KUDLOVICH, Robert ; KIM, Christina A. ; DAWE, David E.
Journal of geriatric oncology, 11/08/2020, Pagination inconnue

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Quality of end-of-life care of advanced cancer patients in mainland China - a retrospective cohort of 441 hospital-death in a public funded comprehensive hospital

LI, Ji Shi ; LAM, Tai-Chung ; JING, Hai Man ; CHEN, Xian ; CAO, Meng Yao ; HUANG, Chun ; YANG, Li ; XU, Zhi Yuan ; JIANG, Yong ; LI, Sha Sha ; CHEN, Fang ; HAN, Ying ; ZHANG, Yong Sheng ; LAM, Ka-On ; LEE, Anne W. M.
Annals of palliative medicine, 14/07/2020, p. 1-8

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