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Physical examination of the dying patient #392

SCHNEIDERMAN, Henry ; MARKS, Sean
JOURNAL OF PALLIATIVE MEDICINE, 05/2020, vol.23, n°5, p. 721-722

How palliative care professionals deal with predicting life expectancy at the end of life - predictors and accuracy

MANDELLI, Sara ; RIVA, Emma ; TETTAMANTI, Mauro ; LUCCA, Ugo ; LOMBARDI, Davide ; MIOLO, Gianmaria ; SPAZZAPAN, Simon ; MARSON, Rita ; VIA DI NATALE HOSPICE INVESTIGATORS
Supportive care in cancer, 31/08/2020, Pagination inconnue

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Characteristics and outcomes of patients with covid-19 at a district general hospital in Surrey, UK

KNIGHTS, Harry ; MAYOR, Nikhil ; MILLAR, Kristina ; COX, Matthew ; BUNOVA, Evgeniya ; HUGHES, Morgan ; BAKER, Jack ; MATHEW, Sanju ; RUSSELL-JONES, David ; KOTWICA, Aleksandra
Clinical medicine, 24/07/2020, p. 1-6

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Comparison of patient self-reported quality of life and health care professional-assessed symptoms in terminally ill patients with cancer

MATSUMURA, Chikako ; KOYAMA, Nanako ; SAKO, Morito ; KUROSAWA, Hideo ; NOMURA, Takehisa ; EGUCHI, Yuki ; OHBA, Kazuki ; YANO, Yoshitaka
The American journal of hospice and palliative care, 24/07/2020, Pagination inconnue

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The need for early referral to palliative care especially for Black, Asian and minority ethnic groups in a covid-19 pandemic - findings from a service evaluation

CHIDIAC, Claude ; FEUER, David J. ; FLATLEY, Mary ; RODGERSON, Anna ; GRAYSON, Kate ; PRESTON, Nancy
PALLIATIVE MEDICINE, 10/2020, vol.34, n°9, p. 1241-1248

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Symptom relief is possible in elderly dying covid-19 patients - a national register study

STRANG, Peter M. ; BERGSTRÖM, Jonas ; LUNDSTRÖM, Staffan
JOURNAL OF PALLIATIVE MEDICINE, 31/07/2020, p. 1-6

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The content validity of the items related to the social and spiritual dimensions of the Utrecht Symptom Diary: 4 dimensional from a patient's perspective - a qualitative study

DE VRIES, Sita ; LORMANS, Tom ; DE GRAAF, Everlien ; LEGET, Carlo ; TEUNISSEN, Saskia
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 07/08/2020, p. 1-10

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A cross-sectional gender-sensitive analysis of depressive symptoms in patients with advanced cancer

SHAPIRO, Gilla K. ; MAH, Kenneth ; DE VRIES, Froukje ; LI, Madeline ; ZIMMERMANN, Camilla ; HALES, Sarah ; RODIN, Gary
PALLIATIVE MEDICINE, 12/08/2020, Pagination inconnue

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Thème : Médecine.

DEPRESSION ; CANCER ; GENRE ; CANADA ; SYMPTOME

Background: Patients with advanced cancer commonly report depressive symptoms. Examinations of gender differences in depressive symptoms in patients with advanced cancer have yielded inconsistent findings.
Aim: The objective of this study was to investigate whether the severity and correlates of depressive symptoms differ by gender in patients with advanced cancer.
Design: Participants completed measures assessing sociodemographic and medical characteristics, disease burden, and psychosocial factors. Depressive symptoms were examined using the Patient Health Questionnaire, and other measures included physical functioning, symptom burden, general anxiety, death related distress, and dimensions of demoralization. A cross-sectional analysis examined the univariate and multivariate relationships between gender and depressive symptoms, while controlling for important covariates in multivariate analyses.
Setting/participants: Patients with advanced cancer (N = 305, 40% males and 60% females) were recruited for a psychotherapy trial from outpatient oncology clinics at a comprehensive cancer center in Canada.
Results: Severity of depressive symptoms was similar for males (M = 7.09, SD = 4.59) and females (M = 7.66, SD = 5.01), t(303) = 1.01, p = 0.314. Greater general anxiety and number of cancer symptoms were associated with depressive symptoms in both males and females. Feeling like a failure (ß = 0.192), less death anxiety (ß = –0.188), severity of cancer symptoms (ß = 0.166), and older age (ß = 0.161) were associated with depressive symptoms only in males, while disheartenment (ß = 0.216) and worse physical functioning (ß = 0.275), were associated with depressive symptoms only in females.
Conclusions: Males and females report similar levels of depressive symptoms but the pathways to depression may differ by gender. These differences suggest the potential for gender-based preventive and therapeutic interventions in this population.

Origine : PubMed

Combined systemic inflammation score (SIS) correlates with prognosis in patients with advanced pancreatic cancer receiving palliative chemotherapy

MARKUS, M. ; ABENDROTH, A. ; NOUREDDINE, R. ; PAUL, A. ; BREITENBUECHER, S. ; VIRCHOW, I. ; SCHMID, K. W. ; MARKUS, P. ; SCHUMACHER, B. ; WIESWEG, M. ; WENDLING, J. ; MENDE, B. ; SIVEKE, J. T. ; SCHULER, M. ; KASPER, S.
Journal of cancer research and clinical oncology, 25/08/2020, p. 1-13

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Thème : Médecine. Cote : eD03.01.01

ETUDE RETROSPECTIVE ; SYMPTOME ; CANCER DIGESTIF ; PRONOSTIC

Purpose: The prognosis of patients with advanced pancreatic ductal adenocarcinoma (PDAC) remains dismal. New cytotoxic agents such as nab-paclitaxel and liposomal irinotecan (nal-Iri) have extended the armamentarium of therapeutic options in the last years. Nowadays, sequential therapeutic strategies with moderately toxic chemotherapeutic protocols can be administered to the patients. However, prognostic and predictive biomarkers are still missing to identify those patients, which profit most from a “continuum of care” concept rather than receiving intensive first-line protocols such as FOLFIRINOX. To this end, we retrospectively evaluated the impact of the systemic inflammation as one essential hallmark of cancer in patients with advanced PDAC treated with sequential systemic.
Methods: A cohort of 193 PDAC patients treated at our center from January 2005 to August 2011 were retrospectively evaluated for the following systemic inflammatory response (SIR) markers: neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR) C-reactive protein (CRP), and the modified Glasgow Prognostic Score (mGPS). SIR markers were correlated with clinico-pathological findings, response to chemotherapy and overall survival (OS) using Kaplan–Meier curves and Cox proportional models.
Results: All evaluated SIR markers were significantly associated with OS in patients with metastatic disease but not in patients with locally advanced PDAC. Interestingly, all SIR markers were only prognostic in patients not receiving antibiotics as surrogate marker for systemic bacterial infections. Based on the evaluated SIR markers, we propose a new Systemic Inflammation Score (SIS), which significantly correlated with reduced OS (HR: 3.418 (1.802–6.488, p < 0.001)) and the likelihood of receiving further-line systemic therapies (p = 0.028).
Conclusion: Routinely assessed SIR biomarkers have potential to support therapeutic decision making in patients with metastatic PDAC.

Origine : PubMed

Are there gender differences in prolonged grief trajectories? - a registry-sampled cohort study

LUNDORFF, Marie ; BONANNO, George A. ; JOHANNSEN, Maja ; O'CONNOR, Maja
Journal of psychiatric research, 01/10/2020, vol.129, p. 168-175

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Frequency and characteristics of first-time palliative care referrals during the last day of life

HEUNG, Yvonne ; AZHAR, Ahsan ; ALI AKBAR NAQVI, Syed Mujtaba ; WILLIAMS, Janet ; PARK, Minjeong ; HUI, David ; DIBAJ, Seyedeh ; LIU, Diane ; BRUERA, Eduardo
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 18/08/2020, p. 1-16

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Palliative care during covid-19 - data and visits from loved ones

HEATH, Laura ; YATES, Sharon ; CAREY, Matthew ; MILLER, Mary G.
The American journal of hospice and palliative care, 11/2020, vol.37, n°11, p. 988-991

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Manuel de soins palliatifs - clinique, psychologie, éthique

LE BERRE, Rozenn
Dunod , 08/2020 , 1260 p.

Oncology to specialised palliative home care systematic transition - the domus randomised trial

BENTHIEN, Kirstine ; DIASSO, Pernille ; VON HEYMANN, Annika ; NORDLY, Mie ; KURITA, Geana ; TIMM, Helle ; JOHANSEN, Christoffer ; KJELLBERG, Jakob ; VON DER MAASE, Hans ; SJOGREN, Per
BMJ supportive and palliative care, 2020, vol.10, n°3, p. 350-357

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Clinically significant depressive symptoms are prevalent in people with extremely short prognoses - a systematic review

LEE, Wei ; PULBROOK, Marley ; SHEEHAN, Caitlin ; KOCHOVSKA, Slavica ; CHANG, Sungwon ; HOSIE, Annmarie ; LOBB, Elizabeth ; PARKER, Deborah ; DRAPER, Brian ; AGAR, Meera R. ; CURROW, David
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 17/07/2020, p. 1-26

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Establishment of a palliative care consultation service (PCCS) in an acute hospital setting

ENGEL, Peter Tom ; THAVAYOGARAJAH, Tharshika ; GORLICH, Dennis ; LENZ, Philipp
International journal of environmental research and public health, 10/07/2020, vol.17, n°14, p. 1-13

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Corticosteroids for common palliative care symptoms #395

CARDENAS-MORI, Jhosselini ; LEWIS-RAMOS, Vanessa
JOURNAL OF PALLIATIVE MEDICINE, 07/2020, vol.23, n°7, p. 987-989

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Content validation of the EORTC QLQ-C15-PAL with advanced cancer patients and health care professionals from palliative care services in Chile

ROJAS-CONCHA, Leslye ; HANSEN, Maiken Bang ; PETERSEN, Morten Aagaard ; GROENVOLD, Mogens
BMC palliative care, 09/06/2020, vol.19, n°1, p. 1-10

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Symptom burden and clinical profile of Covid-19 deaths - a rapid systematic review and evidence summary

KEELEY, Paul ; BUCHANAN, Deans ; CAROLAN, Clare ; PIVODIC, Lara ; TAVABIE, Simon ; NOBLE, Simon
BMJ supportive and palliative care, 28/05/2020, p. 1-4

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Systematic symptom and problem assessment at admission to the palliative care ward - perspectives and prognostic impacts

COYM, Anja ; ULLRICH, Anneke ; HACKSPIEL, Lisa Kathrin ; AHRENHOLZ, Mareike ; BOKEMEYER, Carsten ; OECHSLE, Karin
BMC palliative care, 28/05/2020, vol.19, n°1, p. 1-11

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