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GUPTA, Arjun

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Changes in the place of death for older adults with cancer - reason to celebrate or a risk for unintended disparities?

SEDHOM, Ramy ; KUO, Pei-Lun ; GUPTA, Arjun ; SMITH, Thomas J. ; CHINO, Fumiko ; CARDUCCI, Michael A. ; BANDEEN-ROCHE, Karen
Journal of geriatric oncology, 26/10/2020, Pagination inconnue

Document en ligne

Thème : Santé.

LIEU DECES ; PERSONNE AGEE ; CANCER ; HOPITAL ; MAISON RETRAITE ; DOMICILE ; UNITE SOINS PALLIATIFS

BACKGROUND: Place of death is important to patients and caregivers, and often a surrogate measure of health care disparities. While recent trends in place of death suggest an increased frequency of dying at home, data is largely unknown for older adults with cancer.
METHODS: Deidentified death certificate data were obtained via the National Center for Health Statistics. All lung, colon, prostate, breast, and pancreas cancer deaths for older adults (defined as >65 years of age) from 2003 to 2017 were included. Multinomial logistic regression was used to test for differences in place of death associated with sociodemographic variables.
RESULTS: From 2003 through 2017, a total of 3,182,707 older adults died from lung, colon, breast, prostate and pancreas cancer. During this time, hospital and nursing home deaths decreased, and the rate of home and hospice facility deaths increased (all p < 0.001). In multivariable regression, all assessed variables were found to be associated with place of death. Overall, older age was associated with increased risk of nursing facility death versus home death. Black patients were more likely to experience hospital death (OR 1.7) and Hispanic ethnicity had lower odds of death in a nursing facility (OR 0.55). Since 2003, deaths in hospice facilities rapidly increased by 15%.
CONCLUSION: Hospital and nursing facility cancer deaths among older adults with cancer decreased since 2003, while deaths at home and hospice facilities increased. Differences in place of death were noted for non-white patients and older adults of advanced age.

Origine : PubMed

Chimeric antigen receptor T cell immunotherapy - what you need to know #393

SEDHOM, Ramy ; GUPTA, Arjun ; EL-JAWAHRI, Areej R.
JOURNAL OF PALLIATIVE MEDICINE, 06/2020, vol.23, n°6, p. 863-864

Thème : Médicaments - Pharmacie. Cote : 00.07JOU

IMMUNOTHERAPIE ; CANCER ; TOXICITE ; REMISSION ; COUT SANTE

Immunotherapy using one's own T cells that are genetically engineered to express a chimeric antigen receptor (CAR) is an emerging therapy for hematologic and non-hematologic cancer. CAR T cell therapy has induced rapid and durable clinical responses in otherwise fatal cancers, but is associated with unique, possibly severe, toxicities. This Fast Facts discusses the basics of CAR T cell therapy for clinicians, approved indications, and toxicities.

Oncology fellow-led quality improvement project to improve rates of palliative care utilization in patients with advanced cancer

SEDHOM, Ramy ; GUPTA, Arjun ; SHAH, Mirat ; HSU, Melinda ; MESSMER, Marcus ; MURRAY, Joseph ; BROWNER, Ilene ; SMITH, Thomas J. ; MARRONE, Kristen
JCO oncology practice, 27/04/2020, Pagination inconnue

Document en ligne

Thème : Médecine.

CANCEROLOGIE ; MEDECINE PALLIATIVE ; ACCES SOIN ; INTERDISCIPLINARITE

PURPOSE: ASCO guidelines recommend palliative care (PC) referral for patients with advanced or metastatic cancer. Despite this, implementation has considerable hurdles. First-year oncology fellows at our institution identified low rates of PC utilization in their longitudinal clinic as a metric needing improvement.
METHODS: A fellow-led multidisciplinary team aimed to increase PC utilization for patients with advanced cancer followed in he first-year fellows' clinic from a baseline of 11.5% (5 of 43 patients, July to December of 2018) to 30% over a 6-month period. Utilization was defined as evaluation in the outpatient PC clinic hosted in the cancer center. The team identified the following barriers to referral: orders difficult to find in the electronic medical record (EMR), multiple consulting mechanisms (EMR, by phone, or in person), EMR request not activating formal consult, no centralized scheduler to contact or confirm appointment, and poor awareness of team structure. Plan-Do-Study-Act (PDSA) cycles were implemented based on identified opportunities. Data were obtained from the EMR.
RESULTS: The first PDSA cycle included focus groups with stakeholders, standardizing referral process via single order set, identifying a single scheduler with bidirectional communication, and disseminating process changes. PDSA cycles were implemented from January to June of 2019. Rates of PC use increased from 11.5% before the intervention to 48.4% (48 of 99 patients) after the intervention.
CONCLUSION: A multidisciplinary approach and classic quality improvement methodology improved PC use in patients with advanced cancer. The pilot succeeded given the small number of fellows, buy-in from stakeholders, and institutional and leadership support. Straightforward EMR interventions and ancillary staff use are effective in addressing underreferrals.

Origine : PubMed

Has there been a shift in use of subacute rehabilitation instead of hospice referral since immunotherapy has become available?

YEH, Jonathan C. ; KNIGHT, Louise S. ; KANE, Joyce ; DOBERMAN, Danielle J. ; GUPTA, Arjun ; SMITH, Thomas J.
Journal of oncology practice, 29/08/2019, Pagination inconnue

Document en ligne

Thème : Médecine.

IMMUNOTHERAPIE ; UNITE SOINS PALLIATIFS ; THERAPEUTIQUE ANTI CANCEREUSE ; PARCOURS

PURPOSE: Immunotherapy has rapidly become the mainstream treatment of multiple cancer types. Since the first drug approval in 2011, we have noted a decline in referrals from inpatient oncology to hospice and an increase in referrals to subacute rehabilitation (SAR) facilities, possibly with the aim of getting strong enough for immunotherapy and other promising drugs. This study explores outcomes after discharge to SAR, including rates of cancer-directed therapy after SAR, overall survival, and hospice use.
METHODS: We performed an electronic chart review of patients discharged from our inpatient oncology units to SAR facilities from 2009 to 2017. Demographics, admission statistics, and post-discharge outcomes were gathered from discharge summaries and targeted chart searches.
RESULTS: Three hundred fifty-eight patients were referred to SAR 413 times. One hundred seventy-four patients (49%) returned to the oncology clinic before readmission or death, and only 117 (33%) ever received additional cancer-directed treatment (chemotherapy, radiation, or immunotherapy). Among all discharges, 28% led to readmissions within 30 days. Seventy-four patients (21%) were deceased within 30 days, only 31% of whom were referred to hospice. Palliative care involvement resulted in more frequent do not resuscitate code status, documented goals of care discussions, and electronic advance directives.
CONCLUSION: A growing number of oncology inpatients are being discharged to SAR, but two thirds do not receive additional cancer therapy at any point, including a substantial fraction who are readmitted or deceased within 1 month. These data can help guide decision making and hospital discharge planning that aligns with patients' goals of care. More clinical data are needed to predict who is most likely to benefit from SAR and proceed to further cancer therapy.

Origine : PubMed

Palliative care and end-of-life health care utilization in elderly patients with pancreatic cancer

BHULANI, Nizar ; GUPTA, Arjun ; GAO, Ang ; LI, Jenny ; GUENTHER, Chad ; AHN, Chul ; PAULK, Elizabeth ; HOUCK, Stephanie ; BEG, Muhammad S.
Journal of gastrointestinal oncology, 06/2018, vol.9, n°3, p. 495-502

Document en ligne

Thème : Médecine. Cote : eD03.03.00

DEMARCHE PALLIATIVE ; FIN VIE ; OFFRE SOIN ; PERSONNE AGEE ; CANCER DIGESTIF ; PANCREAS ; TRAJECTOIRE MALADIE

Background: Palliative care has been associated with improved survival and quality of life, with lower rate of end-of-life health care utilization and cost. We examined trends in palliative care utilization in older pancreatic cancer patients.
Methods: Pancreatic cancer patients with and without palliative care consults were identified using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database between 2000 and 2009. Trend of palliative care use was studied. Emergency room/intensive care unit (ICU) utilization and costs in the last 30 days of life were compared between both groups using propensity score-matched (PSM) analysis.
Results: Of the 54,130 patients, 3,166 (5.8%) received palliative care and 70% received it in the last 30 days of life. The proportion of patients receiving palliative care increased from 1.4% in 2000 to 7.4% in 2009 (P<0.001). Patients with palliative care were more likely to be older, Asian and women. In the unmatched and PSM population, the average visits to the ER in the last 30 days of life were significantly higher for patients who received palliative care, and had a significantly higher cost of care. Similarly, ICU length of stay in the last 30 days of life was higher in patients who did not receive palliative care in both PSM and unmatched patients. Cost of care and number of ICU admissions were not different between palliative and non-palliative care groups in PSM and unmatched patients.
Conclusions: In this study of Medicare patients with pancreatic cancer, palliative care use has increased between 2000 and 2009. Palliative care was largely offered close to the end of life and was not associated with reduced health care utilization or cost.

Origine : PubMed

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ACCES SOIN CANCER CANCER DIGESTIF CANCEROLOGIE COUT SANTE DEMARCHE PALLIATIVE DOMICILE FIN VIE HOPITAL IMMUNOTHERAPIE INTERDISCIPLINARITE LIEU DECES MAISON RETRAITE PERSONNE AGEE UNITE SOINS PALLIATIFS

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