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ESSAI CONTROLE RANDOMISE

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Effectiveness of a brief advance directive intervention in primary care - a randomized clinical trial

RANDO-MATOS, Yolanda ; VIVES-ARGILAGOS, Toni ; RODERO-PEREZ, Estrella ; SOLSONA-DIAZ, Lluís ; BALLVE-MORENO, José Luis ; MORENO-FARRES, Noemí ; SORANDO-ALASTRUEY, Rosa ; ADROER-MARTORI, Raquel ; SANFELIU-SOTO, Núria ; ALMEDA-ORTEGA, Jesús
Patient education and counseling, 18/06/2020, Pagination inconnue

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A novel narrative e-writing intervention for parents of children with chronic life-threatening illnesses - protocol for a pilot, open-label randomized controlled trial

HO, Andy Hau Yan ; DUTTA, Oindrila ; TAN-HO, Geraldine ; TAN, Toh Hsiang Benny ; LOW, Casuarine Xinyi ; GANAPATHY, Sashikumar ; CAR, Josip ; HO, Ringo Moon-Ho ; MIAO, Chun Yan
JMIR research protocols, 07/2020, vol.9, n°7, 14 p.

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Evaluation of a novel educational intervention to improve conversations about implantable cardioverter-defibrillators management in patients with advanced heart failure

KWOK, Ian B. ; MATHER, Harriet ; MCKENDRICK, Karen ; GELFMAN, Laura ; HUTCHINSON, Mathew D. ; LAMPERT, Rachel J. ; LIPMAN, Hannah I. ; MATLOCK, Daniel D. ; SWETZ, Keith M. ; KALMAN, Jill ; PINNEY, Sean ; MORRISON, R. Sean ; GOLDSTEIN, Nathan E.
JOURNAL OF PALLIATIVE MEDICINE, 29/06/2020, Pagination inconnue

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A clustered randomized trial informing patients on dialysis about their ability to donate organs and tissues

ANDREWS, Ann M. ; ZHANG, Nanhua ; SMITH, Allyce Haney ; LOUGHERY, Caitlin ; RESNICOW, Ken ; CHAPMAN, Remonia ; JENKINS RILEY, Holly ; STAV, Sheri ; YEE, Jerry
Progress in transplantation, 22/06/2020, Pagination inconnue

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The efficacy of a single session of 20-minute mindful breathing in reducing dyspnea among patients with acute decompensated heart failure - a randomized controlled trial

NG, Diana Leh-Ching ; CHAI, Chee-Shee ; TAN, Kok-Leng ; CHEE, Kok-Han ; TUNG, Yu-Zhen ; WAI, Suet-Yen ; TEO, Wei-Ting Joyce ; ANG, Bin-Ting ; LIM, Min-Ai ; TAN, Seng-Beng
American journal of hospice and palliative medicine, 26/06/2020, Pagination inconnue

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In search of hospice information - consumer information available on hospice compare and yelp

RAHMAN, Anna N. ; ENGUIDANOS, Susan
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 24/06/2020, p. 1-20

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Randomized controlled trial to identify the optimal radiotherapy scheme for palliative treatment of incurable head and neck squamous cell carcinoma

AL-MAMGANI, Abrahim ; KESSELS, Rob ; VERHOEF, Cornelia G. ; NAVRAN, Arash ; HAMMING-VRIEZE, Olga ; KAANDERS, Johannes H. A. M. ; STEENBAKKERS, Roel J. H. M. ; TANS, Lisa ; HOEBERS, Frank ; ONG, Francisca ; VAN WERKHOVEN, Erik ; LANGENDIJK, Johannes A.
Radiotherapy and oncology, 08/2020, vol.149, p. 181-188

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Effect of family centered (FACE®) advance care planning on longitudinal congruence in end-of-life treatment preferences - a randomized clinical trial

LYON, Maureen E. ; SQUIRES, Leah ; SCOTT, Rachel K. ; BENATOR, Debra ; BRIGGS, Linda ; GREENBERG, Isabella ; D'ANGELO, Lawrence J. ; CHENG, Yao Iris ; WANG, Jichuan
AIDS and behavior, 12/05/2020, Pagination inconnue

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Evaluation of a communication skills training to facilitate addressing palliative care related topics in advanced cancer patients - study protocol of a multicenter randomized controlled trial (PALLI-KOM)

HARNISCHFEGER, Nele ; RATH, Hilke M. ; ULLRICH, Anneke ; ALT-EPPING, Bernd ; LETSCH, Anne ; THUSS-PATIENCE, Peter ; BOKEMEYER, Carsten ; OECHSLE, Karin ; BERGELT, Corinna
BMC palliative care, 12/05/2020, vol.19, n°1, p. 1-8

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Feasibility of delivering a tailored intervention for advance care planning in primary care practice

PAIVA, Andrea ; REDDING, Colleen A. ; IANNONE, Lynne ; ZENONI, Maria ; O'LEARY, John R. ; FRIED, Terri R.
Journal of the American Geriatrics Society, 01/01/2019, vol.67, n°9, p. 1917-1921

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Effects of early and systematic integration of specialist palliative care in patients with advanced cancer - randomized controlled trial PALINT

SLAMA, Ondrej ; POCHOP, Lukas ; SEDO, Jiri ; SVANCARA, Jan ; SEDOVA, Petra ; SVETLAKOVA, Lucie ; DEMLOVA, Regina ; VYZULA, Rostislav
JOURNAL OF PALLIATIVE MEDICINE, 08/05/2020, Pagination inconnue

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Thème : Médecine.

DEMARCHE PALLIATIVE ; CANCER ; ESSAI CONTROLE RANDOMISE ; REPUBLIQUE TCHEQUE ; QUALITE VIE

Background: A broad consensus on the optimal structure, intensity, and timing of early specialist palliative care (SPC) intervention is lacking.
Objective: To evaluate the benefit of an early and systematic palliative intervention alongside standard oncology care compared with standard oncology care alone in patients with advanced solid tumors.
Design: PALINT, a single-center RCT, conducted at the Masaryk Memorial Cancer Institute, the largest comprehensive cancer center in the Czech Republic (CR).
Setting/Subjects/Measurements: Patients with newly diagnosed advanced cancer within six weeks from the start of the palliative systemic therapy were randomly assigned to the integration of SPC (intervention; a consultation with a PC physician every six to eight weeks) or to the standard oncology care (control). The primary endpoint was the quality of life (QOL) assessed by EORTC QLQ C30 and Hospital Anxiety and Depression Scale (HADS) at three and six months.
Results: From 2015 to 2017, a total of 126 patients were randomly assigned to intervention (60) or to control (66) arm. At baseline, at three and six months, the global QOL scores (mean, 95% CI) in the intervention and control arm were 58.6 (53.9–63.3), 61.9 (56.4–67.4) and 66.7 (60.2–73.2) versus 54.2 (49.4–58.9), 59.0 (53.7–64.3), and 62.8 (56.7–68.9), respectively. The prevalence of anxiety (HADS-A; value >7) was 36.7%, 27.5%, and 18.9% versus 34.8%, 23.5%, and 16.3% and the prevalence of depression (HADS-D; value >7) was 28.3%, 25.4%, and 29.7% versus 28.8%, 29.4%, and 27.9%, respectively. There was no significant difference between the two arms. The overall survival was similar in both arms (347 vs. 310 days; p = 0.203).
Conclusions: A model of early integration of SPC consisting of a consultation with a PC physician alone every six to eight weeks did not increase the QOL of patients with advanced cancer compared with routine oncology care in a center with widely available supportive services. These negative results underline the importance of the multidisciplinary patient centered approach in the early SPC.

Origine : PubMed

Effects of a communication intervention randomized controlled trial to enable goals-of-care discussions

BICKELL, Nina A. ; BACK, Anthony L. ; ADELSON, Kerin ; GONSKY, Jason P. ; EGOROVA, Natalia ; PINTOVA, Sofya ; LIN, Jenny J. ; KOZUCH, Peter ; BAGIELLA, Emilia ; SMITH, Cardinale B.
JCO oncology practice, 06/05/2020, Pagination inconnue

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Complementary music therapy for cancer patients in at-home palliative care and their caregivers - protocol for a multicentre randomised controlled trial

VALERO-CANTERO, Inmaculada ; MARTINEZ-VALERO, Francisco Javier ; ESPINAR-TOLEDO, Milagrosa ; CASALS, Cristina ; BARON-LOPEZ, Francisco Javier ; VAZQUEZ-SANCHEZ, Maria Angeles
BMC palliative care, 02/05/2020, vol.19, n°1, p. 1-11

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Study protocol for a cluster randomised controlled feasibility trial evaluating personalised care planning for older people with frailty - PROSPER V2 27/11/18

HEAVEN, Anne ; BOWER, Peter ; CUNDILL, Bonnie ; FARRIN, Amanda ; FOSTER, Marilyn ; FOY, Robbie ; HARTLEY, Suzanne ; HAWKINS, Rebecca ; HULME, Claire ; HUMPHREY, Sara ; LAWTON, Rebecca ; PARKER, Catriona ; PENDLETON, Neil ; WEST, Robert ; YOUNG, John ; CLEGG, Andrew
Pilot and feasibility studies, 2020, vol.6, p. 1-11

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A multicomponent nonpharmacological intervention to prevent delirium for hospitalized people with advanced cancer - a phase II cluster randomized waitlist controlled trial (the preserve pilot study)

HOSIE, Annmarie ; PHILLIPS, Jane ; LAM, Lawrence ; KOCHOVSKA, Slavica ; NOBLE, Beverly ; BRASSIL, Meg ; KURRLE, Susan ; CUMMING, Anne ; CAPLAN, Gideon A. ; CHYE, Richard ; ELY, Eugene Wesley ; LAWLOR, Peter G. ; BUSH, Shirley H. ; DAVIS, Jan Maree ; LOVELL, Melanie ; PARR, Cynthia ; WILLIAMS, Sally ; HAUSER, Katherine ; MCARDLE, Susan ; JACQUIER, Karen ; PHILLIPSON, Carl ; KUWAHATA, Lynne ; KERFOOT, Jackie ; BROWN, Linda ; FAZEKAS, Belinda ; CHEAH, Seong Leang ; EDWARDS, Layla ; GREEN, Anna ; HUNT, Jane ; ATTWOOD, Robyn ; ASSEN, Teresa ; GARCIA, Maja ; WILCOCK, Julie ; AGAR, Meera
JOURNAL OF PALLIATIVE MEDICINE, 24/04/2020, Pagination inconnue

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Thème : Médecine.

DELIRE ; CANCER ; AUSTRALIE ; PRATIQUE ALTERNATIVE ; ESSAI CONTROLE RANDOMISE

Background: Delirium is a common debilitating complication of advanced cancer.
Objective: To determine if a multicomponent nonpharmacological delirium prevention intervention was feasible for adult patients with advanced cancer, before a phase III (efficacy) trial.
Design: Phase II (feasibility) cluster randomized controlled trial. All sites implemented delirium screening and diagnostic assessment. Strategies within sleep, vision and hearing, hydration, orientation, mobility, and family domains were delivered to enrolled patients at intervention site admission days 1–7. Control sites then implemented the intervention (“waitlist sites”).
Setting: Four Australian palliative care units.
Measurements: The primary outcome was adherence, with an a priori endpoint of at least 60% patients achieving full adherence. Secondary outcomes were interdisciplinary care delivery, delirium measures, and adverse events, analyzed descriptively and inferentially.
Rsults: Sixty-five enrolled patients (25 control, 20 intervention, and 20 waitlist) had 98% delirium screens and 75% diagnostic assessments completed. Nurses (67%), physicians (16%), allied health (8.4%), family (7%), patients (1%), and volunteers (0.5%) delivered the intervention. There was full adherence for 5% patients at intervention sites, partial for 25%. Both full and partial adherence were higher at waitlist sites: 25% and 45%, respectively. One-third of control site patients (32%) became delirious within seven days of admission compared to one-fifth (20%) at both intervention and waitlist sites (p = 0.5). Mean (standard deviation) Delirium Rating Scale-Revised-1998 scores were 16.8 + 12.0 control sites versus 18.4 + 8.2 (p = 0.6) intervention and 18.7 + 7.8 (p = 0.5) waitlist sites. The intervention caused no adverse events.
Conclusion: The intervention requires modification for optimal adherence in a phase III trial.

Origine : PubMed

Economic evaluation of a combined screening and stepped-care treatment program targeting psychological distress in patients with metastatic colorectal cancer - a cluster randomized controlled trial

EL ALILI, Mohamed ; SCHUURHUIZEN, Claudia S. E. W. ; BRAAMSE, Annemarie M. J. ; BEEKMAN, Aartjan T. F. ; VAN DER LINDEN, Mecheline H. ; KONINGS, Inge R. ; DEKKER, Joost ; BOSMANS, Judith E.
PALLIATIVE MEDICINE, 29/04/2020, p. 1-12

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Summarizing the evidence base for palliative oncology care - a critical evaluation of the meta-analyses

ROGERS, James L. ; PERRY, Laura M. ; HOERGER, Michael
Clinical medicine insights. Oncology, 2020, vol.14, p. 1-5

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How short is too short? - a randomised controlled trial evaluating short-term existential behavioural therapy for informal caregivers of palliative patients

KUHNEL, Martina B. ; MARCHIORO, Linda ; DEFFNER, Veronika ; BAUSEWEIN, Claudia ; SEIDL, Hildegard ; SIEBERT, Sarah ; FEGG, Martin
PALLIATIVE MEDICINE, 2020, vol.34, n°6, p. 806-816

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Protocol for a randomised trial of an interprofessional team-delivered intervention to support surrogate decision-makers in ICUs

LINCOLN, Taylor ; SHIELDS, Anne-Marie ; BUDDADHUMARUK, Praewpannarai ; CHANG, Chung-Chou H ; PIKE, Francis ; CHEN, Hsiangyu ; BROWN, Elke ; KOZAR, Veronica ; PIDRO, Caroline ; KAHN, Jeremy M ; DARBY, Joseph M ; MARTIN, Susan ; ANGUS, Derek C ; ARNOLD, Robert M ; WHITE, Douglas B
BMJ Open, 03/2020, vol.10, n°3, p. 1-12

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