VigiPallia : Résultats

ESSAI RANDOMISE

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Randomized trial of a hospice video educational tool for patients with advanced cancer and their caregivers - hospice video in advanced cancer

EL-JAWAHRI, Areej ; TRAEGER, Lara ; GREER, Joseph A. ; VANBENSCHOTEN, Olivia ; MARKOVITZ, Netana ; CASHAVELLY, Barbara ; TATA, Lee Ann ; NIPP, Ryan D. ; REYNOLDS, Kerry L. ; GOYAL, Lipika ; BHATT, Sunil ; FISHMAN, Sarah ; HORICK, Nora ; LI, Zhigang ; VOLANDES, Angelo ; TEMEL, Jennifer S.
Cancer, 08/06/2020, Pagination inconnue

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A randomised phase II trial testing the acceptability and feasibility of a narrative approach to public health communication to increase community engagement with palliative care

COLLINS, Anna ; MCLACHLAN, Sue-Anne ; HILL, Mike ; COLLINS, Sue ; PHILIP, Jennifer
PALLIATIVE MEDICINE, 19/06/2020, Pagination inconnue

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A randomized, placebo-controlled, double-blind study of mocycline for reducing the symptom burden experienced by patients with advanced pancreatic cancer

KAMAL, Mona ; WANG, Xin Shelley ; SHI, Qiuling ; MENDOZA, Tito ; GARCIA-GONZALEZ, Araceli ; BOKHARI, Raza H. ; CLEELAND, Charles S. ; FOGELMAN, David R.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 05/2020, vol.59, n°5, p. 1052-1058

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Impact of a nurse-led advance care planning intervention on satisfaction, health-related quality of life, and health care utilization among patients with severe respiratory disease - a randomized patient-preference trial

SINCLAIR, Craig ; AURET, Kirsten Anne ; EVANS, Sharon Frances ; JANE, Fiona ; DORMER, Siobhan ; WILKINSON, Anne ; GREEVE, Kim ; KOAY, M. Audrey ; BRIMS, Fraser
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 04/2020, vol.59, n°4, p. 848-855

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Pilot randomized trial of a transdisciplinary geriatric and palliative care intervention for older adults with cancer

NIPP, Ryan D. ; TEMEL, Brandon ; FUH, Charn-Xin ; KAY, Paul ; LANDAY, Sophia ; LAGE, Daniel ; FRANCO-GARCIA, Esteban ; SCOTT, Erin ; STEVENS, Erin ; O'MALLEY, Terrence ; MOHILE, Supriya ; DALE, William ; TRAEGER, Lara ; JACKSON, Vicki ; GREER, Joseph A. ; EL-JAWAHRI, Areej ; TEMEL, Jennifer S.
Journal of the national comprehensive cancer network, 05/2020, vol.18, n°5, p. 591-598

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A novel decision aid to help plan for serious illness - a multisite randomized trial

HEYLAND, Daren K. ; HEYLAND, Rebecca ; BAILEY, Alice ; HOWARD, Michelle
CMAJ open, 06/2020, vol.8, n°2, p. E289-E296

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Palliative care benefits patients with Parkinson disease

SLOMSKI, Anita
JAMA, 28/04/2020, vol.323, n°16, p. 1543

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Subcutaneous lidocaine for cancer-related pain

HAWLEY, Philippa ; FYLES, Gillian ; JEFFERYS, Stephen G.
JOURNAL OF PALLIATIVE MEDICINE, 27/04/2020, Pagination inconnue

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Thème : Médecine. Cote : eD03.03.00

DEMARCHE PALLIATIVE ; CANCER ; NORVEGE ; ESSAI RANDOMISE

Background: Several publications have addressed the need for a systematic integration of oncological care focused on the tumor and palliative care (PC) focused on the patient with cancer. The exponential increase in anticancer treatments and the high number of patients living longer with advanced disease have accentuated this. Internationally, there is now a persuasive argument that introducing PC early during anticancer treatment in patients with advanced disease has beneficial effects on symptoms, psychological distress, and survival.
Methods: This is a national cluster-randomized trial (C-RCT) in 12 Norwegian hospitals. The trial investigates effects of early, systematic integration of oncology and specialized PC in patients with advanced cancer in six intervention hospitals compared with conventional care in six. Hospitals are stratified on the size of local catchment areas before randomization. In the intervention hospitals, a three-part complex intervention will be implemented. The backbone of the intervention is the development and implementation of patient-centered care pathways that contain early, compulsory referral to PC and regular and systematic registrations of symptoms. An educational program must be completed before patient inclusion. A total of 680 patients with advanced cancer and one caregiver per patient are included when patients come for start of last line of chemotherapy, defined according to national treatment guidelines. Data registration, clinical variables, and patient- and caregiver-reported outcomes take place every 2 months for 1 year or until death. The primary outcome is use of chemotherapy in the last 3 months of life by comparing the proportion of patients who receive this in the intervention and control groups. Primary outcome is use of chemotherapy in the last 3 months before death, i.e. number of patients. Secondary outcomes are initiation, discontinuation and number of cycles, last 3 months of life, administration of other medical interventions in the last month of life, symptom burden, quality of life (QoL), satisfaction with information and follow-up, and caregiver health, QoL, and satisfaction with care.
Discussion: Results from this C-RCT will be used to raise the awareness about the positive outcomes of early provision of specialized palliative care using pathways for patients with advanced cancer receiving medical anticancer treatment. The long-term clinical objective is to integrate these patient-centered pathways in Norwegian cancer care. The specific focus on the patient and family and the organization of a predictable care trajectory is consistent with current Norwegian strategies for cancer care.

Origine : DOI.org (Crossref

Transcutaneous electrical nerve stimulation for advanced cancer pain inpatients in specialist palliative care - a blinded, randomized, sham-controlled pilot cross-over trial

SIEMENS, Waldemar ; BOEHLKE, Christopher ; BENNETT, Michael I. ; OFFNER, Klaus ; BECKER, Gerhild ; GAERTNER, Jan
Supportive care in cancer, 03/03/2020, p. 1-11

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A randomized trial of a multi-level intervention to improve advance care planning and symptom management among low-income and minority employees diagnosed with cancer in outpatient community settings

PATEL, Manali I. ; KHATEEB, Sana ; COKER, Tumaini
Contemporary clinical trials, 04/2020, vol.91, Pagination inconnue

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Empowering older adults to discuss advance care planning during clinical visits - the PREPARE randomized trial

FREYTAG, Jennifer ; STREET, Richard L. ; BARNES, Deborah E. ; SHI, Ying ; VOLOW, Aiesha M. ; SHIM, Janet K. ; ALEXANDER, Stewart C. ; SUDORE, Rebecca L.
Journal of the American Geriatrics Society, 10/03/2020, Pagination inconnue

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A randomised, double-blind, crossover, dose ranging study to determine the optimal dose of oral opioid to treat breakthrough pain for patients with advanced cancer already established on regular opioids

CURROW, David ; CLARK, K. ; LOUW, S. ; FAZEKAS, Belinda ; GREENE, A. ; SANDERSON, C. R.
European journal of pain, 15/02/2020, Pagination inconnue

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Comparison of integrated outpatient palliative care with standard care in patients with Parkinson disease and related disorders - a randomized clinical trial

KLUGER, Benzi M. ; MIYASAKI, Janis ; KATZ, Maya ; GALIFIANAKIS, Nicholas ; HALL, Kirk ; PANTILAT, Steven ; KHAN, Ryan ; FRIEDMAN, Cari ; CERNIK, Wendy ; GOTO, Yuika ; LONG, Judith ; FAIRCLOUGH, Diane ; SILLAU, Stefan ; KUTNER, Jean S.
JAMA neurology, 10/02/2020, p. 1-10

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Multisite, randomized trial of early integrated palliative and oncology care in patients with advanced lung and gastrointestinal cancer - alliance A221303

TEMEL, Jennifer S. ; SLOAN, Jeff A. ; ZEMLA, Tyler ; GREER, Joseph A. ; JACKSON, Vicki A. ; EL-JAWAHRI, Areej ; KAMDAR, Mihir ; KAMAL, Arif ; BLINDERMAN, Craig D. ; STRAND, Jacob ; ZYLLA, Dylan ; DAUGHERTY, Christopher ; FURQAN, Muhummad ; OBEL, Jennifer ; RAZAQ, Mohammad ; ROELAND, Eric J. ; LOPRINZI, Charles
JOURNAL OF PALLIATIVE MEDICINE, 07/2020, vol.23, n°7, p. 922-929

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Intravenous versus subcutaneous route pharmacokinetics of paracetamol (acetaminophen) in palliative care patients - study protocol for a randomized trial (ParaSCIVPallia)

VERNANT, Marine ; LEPOUPET, Marie ; CREVEUIL, Christian ; ALIX, Antoine ; GOURIO, Charlotte ; PEYRO-SAINT-PAUL, Laure ; LELONG-BOULOUARD, Veronique ; GUILLAUME, Cyril
Trials, 04/02/2020, vol.21, n°1, p. 1-7

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A randomized trial of a specialist palliative care intervention for patients undergoing surgery for cancer - rationale and design of the surgery for cancer with option of palliative care expert (SCOPE) trial

SHINALL, Myrick C. ; HOSKINS, Aimee ; HAWKINS, Alexander T. ; BAILEY, Christina ; BROWN, Alaina ; AGARWAL, Rajiv ; DUGGAN, Maria C. ; BESKOW, Laura M. ; PERIYAKOIL, Vyjeyanthi S. ; PENSON, David F. ; JARRETT, Ryan T. ; CHANDRASEKHAR, Rameela ; ELY, E. Wesley
Trials, 11/12/2019, vol.20, n°1, p. 1-11

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Oral medicinal cannabinoids to relieve symptom burden in the palliative care of patients with advanced cancer - a double-blind, placebo controlled, randomised clinical trial of efficacy and safety of cannabidiol (CBD)

GOOD, Phillip ; HAYWOOD, Alison ; GOGNA, Gauri ; MARTIN, Jennifer ; YATES, Patsy ; GREER, Ristan ; HARDY, Janet
BMC palliative care, 06/12/2019, vol.18, n°1, p. 1-7

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The acute kidney outreach to prevent deterioration and death trial - a large pilot study for a cluster-randomized trial

THOMAS, Mark E. ; ABDELAZIZ, Tarek S. ; PERKINS, Gavin D. ; SITCH, Alice J. ; BAHARANI, Jyoti ; TEMPLE, R. Mark
Nephrology, dialysis, transplantation, 20/12/2019, Pagination inconnue

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