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Advance care planning in patients with advanced cancer - a 6-country, cluster-randomised clinical trial

KORFAGE, Ida J. ; CARRERAS, Giulia ; ARNFELDT CHRISTENSEN, Caroline M. ; BILLEKENS, Pascalle ; BRAMLEY, Louise ; BRIGGS, Linda ; BULLI, Francesco ; CASWELL, Glenys ; CERV, Branka ; VAN DELDEN, Johannes J. M. ; DELIENS, Luc ; DUNLEAVY, Lesley ; EECLOO, Kim ; GORINI, Giuseppe ; GROENVOLD, Mogens ; HAMMES, Bud ; INGRAVALLO, Francesca ; JABBARIAN, Lea J. ; KARS, Marijke C. ; KODBA-CEH, Hana ; LUNDER, Urska ; MICCINESI, Guido ; MIMIC, Alenka ; OZBIC, Polona ; PAYNE, Sheila ; POLINDER, Suzanne ; POLLOCK, Kristian ; PRESTON, Nancy J. ; SEYMOUR, Jane Elizabeth ; SIMONIC, Anja ; THIT JOHNSEN, Anna ; TOCCAFONDI, Alessandro ; VERKISSEN, Mariëtte N. ; WILCOCK, Andrew ; ZWAKMAN, Marieke ; VAN DER HEIDE, Agnes ; RIETJENS, Judith A. C.
PLOS MEDICINE, 11/2020, vol.17, n°11, p. 1-16

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Quality of life and added value of a tailored palliative care intervention in patients with soft tissue sarcoma undergoing treatment with trabectedin - a multicentre, cluster-randomised trial within the German interdisciplinary sarcoma group (GISG)

HENTSCHEL, Leopold ; RICHTER, Stephan ; KOPP, Hans-Georg ; KASPER, Bernd ; KUNITZ, Annegret ; GRUNWALD, Viktor ; KESSLER, Torsten ; CHEMNITZ, Jens Marcus ; PELZER, Uwe ; SCHULER, Ulrich ; FREITAG, Janet ; SCHILLING, Andrea ; HORNEMANN, Beate ; ARNDT, Karin ; BORNHAUSER, Martin ; SCHULER, Markus Kajo
BMJ Open, 27/08/2020, vol.10, n°8, p. 1-9

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A population-based mortality follow-back survey evaluating good death for cancer and non-cancer patients - a randomized feasibility study

NAKAZAWA, Yoko ; TAKEUCHI, Emi ; MIYASHITA, Mitsunori ; SATO, Kazuki ; OGAWA, Asao ; KINOSHITA, Hiroya ; KIZAWA, Yoshiyuki ; MORITA, Tatsuya ; KATO, Masashi
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 22/07/2020, p. 1-14

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Community Tele-pal - a community-developed, culturally based palliative care tele-consult randomized controlled trial for African American and White Rural Southern elders with a life-limiting illness

WATTS, Kristen Allen ; GAZAWAY, Shena ; MALONE, Emily ; ELK, Ronit ; TUCKER, Rodney ; MCCAMMON, Susan ; GOLDHAGEN, Michele ; GRAHAM, Jacob ; TASSIN, Veronica ; HAUSER, Joshua ; RHOADES, Sidney ; KAGAWA-SINGER, Marjorie ; WALLACE, Eric ; MCELLIGOTT, James ; KENNEDY, Richard ; BAKITAS, Marie
Trials, 23/07/2020, vol.21, n°1, p. 1-16

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A stepped-wedge randomised-controlled trial assessing the implementation, impact and costs of a prospective feedback loop to promote appropriate care and treatment for older patients in acute hospitals at the end of life - study protocol

LEE, Xing J. ; FARRINGTON, Alison ; CARTER, Hannah ; SHIELD, Carla ; GRAVES, Nicholas ; MCPHAIL, Steven M. ; HARVEY, Gillian ; WHITE, Ben P. ; WILLMOTT, Lindy ; CARDONA, Magnolia ; HILLMAN, Ken ; CALLAWAY, Leonie ; BARNETT, Adrian G.
BMC GERIATRICS, 29/07/2020, vol.20, n°1, p. 1-9

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A question prompt list for advanced cancer patients promoting advance care planning - a French randomised trial

BOULEUC, C. ; SAVIGNONI, A. ; CHEVRIER, M. ; RENAULT-TESSIER, E. ; BURNOD, A. ; CHVETZOFF, Gisèle ; POULAIN, Philippe ; COPEL, L. ; COTTU, P. ; PIERGA, J. Y. ; BRÉDART, A. ; DOLBEAULT, S.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 30/07/2020, p. 1-19

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Effectiveness of advance care planning group visits among older adults in primary care

LUM, Hillary D. ; DUKES, Joanna ; DADDATO, Andrea E. ; JUAREZ-COLUNGA, Elizabeth ; SHANBHAG, Prajakta ; KUTNER, Jean S. ; LEVY, Cari R. ; SUDORE, Rebecca L.
Journal of the American Geriatrics Society, 29/07/2020, Pagination inconnue

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The effect of disclosing life expectancy information on patients' prognostic understanding - secondary outcomes from a multicenter randomized trial of a palliative chemotherapy educational intervention

ENZINGER, Andrea ; UNO, Hajime ; MCCLEARY, Nadine ; FRANK, Elizabeth ; SANOFF, Hanna ; VAN LOON, Katherine ; MATIN, Khalid ; BULLOCK, Andrea ; CRONIN, Christine ; BAGLEY, Janet ; SCHRAG, Deborah
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 07/08/2020, p. 1-14

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Symptom burden and unmet needs in MPM - exploratory analyses from the respect-meso study

HOON, Siao Nge ; LAWRIE, Iain ; QI, Cathy ; RAHMAN, Najib ; MASKELL, Nick A. ; FORBES, Karen ; GERRY, Stephen ; MONTEROSSO, Leanne ; CHAUHAN, Anoop ; BRIMS, Fraser J. H.
JOURNAL OF PALLIATIVE CARE, 14/08/2020, Pagination inconnue

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Thème : Médecine.

MALADIE RESPIRATOIRE ; MEDECINE PALLIATIVE ; QUALITE VIE ; ESSAI RANDOMISE ; CONTROLE SYMPTOME

Objective: Malignant Pleural Mesothelioma (MPM) has a poor prognosis and high symptom burden. RESPECT-Meso was a multicenter randomized study examining the role of early specialist palliative care (SPC) on quality of life (QoL) with MPM. This is a post-hoc exploratory analysis of the symptom burden and unmet needs identified from RESPECT-Meso participants.
Methods: Exploratory analysis from 174 participants using the General Health Status (GHS) measure (from the EORTC QLQ-C30 QoL questionnaire) and 87 participants using validated assessment questionnaires in those randomized to SPC. Eligibility for the study included confirmed MPM with diagnosis <6 weeks prior, performance score (PS) 0 or 1, no significant physical or psychological comorbidity. Cox proportional hazards models were derived to examine for relationships with survival. Free text was assessed using content analysis, looking for common themes and words.
Results: Participants were predominantly male (79.9%), mean age 72.8 years, PS was 0 in 38%, 78% of MPM was epithelioid. At least 3 symptoms were reported in 69.8% of participants, including fatigue (81%), dyspnea (73.3%), pain (61.2%), weight loss (59.3%). Anxiety was reported by 54.7% of participants, 52.3% low mood and 48.8% anhedonia symptoms. After multivariable adjustment, only pain remained statistically significant with a hazard ratio (HR) 2.9 (95% CI 1.3-6.7; p = 0.01). For each 1 unit increase in GHS score, the HR for death was 0.987 (0.978-0.996; p = 0.006), indicating a worse reported QoL is related to shorter survival. Unmet needs were common: 25.9% wanted more information about their condition, 24.7% about their care and 21.2% about their treatment. 79.1% were concerned about the effect of their illness on family.
Conclusion: There is a high symptom burden in mesothelioma despite good baseline performance status. A worse QoL is associated with a worse survival. Unmet needs are common, perhaps highlighting a need for improved communication and information sharing.

Origine : SAGE Journals

Advance care planning: promoting effective and aligned communication in the elderly (ACP-PEACE) - the study protocol for a pragmatic stepped-wedge trial of older patients with cancer

LAKIN, Joshua R. ; BRANNEN, Elise N. ; TULSKY, James A. ; PAASCHE-ORLOW, Michael K. ; LINDVALL, Charlotta ; CHANG, Yuchiao ; GUNDERSEN, Daniel A. ; EL-JAWAHRI, Areej ; VOLANDES, Angelo ; ACP-PEACE INVESTIGATORS
BMJ Open, 14/07/2020, vol.10, n°7, p. 1-10

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Comparison of web-based and paper advance directives - a pilot randomized clinical trial

ROLNICK, Joshua A. ; OREDEKO, Francisca ; COONEY-ZINGMAN, Elizabeth ; ASCH, David A. ; HALPERN, Scott D.
The American journal of hospice and palliative care, 10/07/2020, Pagination inconnue

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Randomized trial of a hospice video educational tool for patients with advanced cancer and their caregivers - hospice video in advanced cancer

EL-JAWAHRI, Areej ; TRAEGER, Lara ; GREER, Joseph A. ; VANBENSCHOTEN, Olivia ; MARKOVITZ, Netana ; CASHAVELLY, Barbara ; TATA, Lee Ann ; NIPP, Ryan D. ; REYNOLDS, Kerry L. ; GOYAL, Lipika ; BHATT, Sunil ; FISHMAN, Sarah ; HORICK, Nora ; LI, Zhigang ; VOLANDES, Angelo ; TEMEL, Jennifer S.
Cancer, 08/06/2020, Pagination inconnue

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A randomised phase II trial testing the acceptability and feasibility of a narrative approach to public health communication to increase community engagement with palliative care

COLLINS, Anna ; MCLACHLAN, Sue-Anne ; HILL, Mike ; COLLINS, Sue ; PHILIP, Jennifer
PALLIATIVE MEDICINE, 19/06/2020, Pagination inconnue

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A randomized, placebo-controlled, double-blind study of mocycline for reducing the symptom burden experienced by patients with advanced pancreatic cancer

KAMAL, Mona ; WANG, Xin Shelley ; SHI, Qiuling ; MENDOZA, Tito ; GARCIA-GONZALEZ, Araceli ; BOKHARI, Raza H. ; CLEELAND, Charles S. ; FOGELMAN, David R.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 05/2020, vol.59, n°5, p. 1052-1058

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Impact of a nurse-led advance care planning intervention on satisfaction, health-related quality of life, and health care utilization among patients with severe respiratory disease - a randomized patient-preference trial

SINCLAIR, Craig ; AURET, Kirsten Anne ; EVANS, Sharon Frances ; JANE, Fiona ; DORMER, Siobhan ; WILKINSON, Anne ; GREEVE, Kim ; KOAY, M. Audrey ; BRIMS, Fraser
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 04/2020, vol.59, n°4, p. 848-855

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Pilot randomized trial of a transdisciplinary geriatric and palliative care intervention for older adults with cancer

NIPP, Ryan D. ; TEMEL, Brandon ; FUH, Charn-Xin ; KAY, Paul ; LANDAY, Sophia ; LAGE, Daniel ; FRANCO-GARCIA, Esteban ; SCOTT, Erin ; STEVENS, Erin ; O'MALLEY, Terrence ; MOHILE, Supriya ; DALE, William ; TRAEGER, Lara ; JACKSON, Vicki ; GREER, Joseph A. ; EL-JAWAHRI, Areej ; TEMEL, Jennifer S.
Journal of the national comprehensive cancer network, 05/2020, vol.18, n°5, p. 591-598

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A novel decision aid to help plan for serious illness - a multisite randomized trial

HEYLAND, Daren K. ; HEYLAND, Rebecca ; BAILEY, Alice ; HOWARD, Michelle
CMAJ open, 06/2020, vol.8, n°2, p. E289-E296

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