VigiPallia : Résultats

Association between the timing of goals-of-care discussion and hospitalization outcomes in patients with metastatic cancer

EMILOJU, Oluwadunni E. ; DJIBO, Djeneba Audrey M. ; FORD, Jean G.
The American journal of hospice and palliative care, 06/2020, vol.37, n°6, p. 433-438

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Four conversations - a randomized controlled trial of an online, personalized coping, and decision aid for metastatic breast cancer patients

SMITH, Sophia K. ; WESTBROOK, Kelly ; MACDERMOTT, Kristin ; AMARASEKARA, Sarthya ; LEBLANC, Matthew ; PAN, Wei
JOURNAL OF PALLIATIVE MEDICINE, 03/2020, vol.23, n°3, p. 353-358

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Trends in palliative surgical care

WILCOX, Allison R. ; WONG, Sandra L.
Advances in surgery, 17/05/2019, Pagination inconnue

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Experiences with prescribing large quantities of systemic anticancer therapy near death

BAENA-CANADA, José M. ; CAMPINI BERMEJO, Alicia ; GAMEZ CASADO, Salvador ; RODRIGUEZ PEREZ, Lourdes ; QUÍLEZ CUTILLAS, Alicia ; CALVETE CANDENAS, Julio ; MARTINEZ BAUTISTA, María J. ; BENITEZ RODRÍGUEZ, Encarnacion
JOURNAL OF PALLIATIVE MEDICINE, 12/2019, vol.22, n°12, p. 1515-1521

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Early venous thromboembolism at the beginning of palliative chemotherapy is a poor prognostic factor in patients with metastatic pancreatic cancer - a retrospective study

KIM, Jung Sun ; KANG, Eun Joo ; KIM, Dae Sik ; CHOI, Yoon Ji ; LEE, Suk Young ; KIM, Hong Jun ; SEO, Hee Yeon ; KIM, Jun Suk
BMC Cancer, 17/12/2018, vol.18, n°1, p. 1260-

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One step forward, two steps back - trends in aggressive inpatient care at the end of life for patients with stage IV lung cancer

MRAD, Chebli ; ABOUGERGI, Marwan S. ; DALY, Bobby
Journal of oncology practice, 28/09/2018, p. 1-13

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Being critical of critical care given to people with metastatic cancer - get palliative care involved

MEHMOOD, Talha ; SMITH, Thomas J.
Journal of the national comprehensive cancer network, 09/2018, vol.16, n°9, p. 1157-1158

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Use of inpatient palliative care services in patients with advanced cancer receiving critical care therapies

LOH, Kah Poh ; ABDALLAH, Maya ; SHIEH, Meng-Shiou ; STEFAN, Mihaela S. ; PEKOW, Penelope S. ; LINDENAUER, Peter K. ; MOHILE, Supriya G. ; BABU, Dilip ; LAGU, Tara
Journal of the national comprehensive cancer network, 09/2018, vol.16, n°9, p. 1055-1064

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Randomized phase II trial evaluating pain response in patients with spinal metastases following stereotactic body radiotherapy versus three-dimensional conformal radiotherapy

SPRAVE, Tanja ; VERMA, Vivek ; FÖRSTER, Robert ; SCHLAMPP, Ingmar ; BRUCKNER, Thomas ; BOSTEL, Tilman ; WELTE, Stefan Ezechiel ; TONNDORF-MARTINI, Eric ; NICOLAY, Nils Henrik ; DEBUS, Jürgen ; RIEF, Harald
Radiotherapy and oncology, 08/2018, vol.128, n°2, p. 274-282

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Thème : Médecine. Cote : eD03.05

ESSAI CONTROLE RANDOMISE ; CONTROLE DOULEUR ; RADIOTHERAPIE ; METASTASE

Background: To report the primary endpoint of a randomized trial comparing pain response following palliative stereotactic body radiation therapy (SBRT) versus conventionally-fractionated 3D-conformal radiotherapy (3DCRT) for previously untreated spinal metastases.
Methods: Fifty-five patients with histologically/radiologically confirmed painful spinal metastases were analyzed in this single-institutional, non-blinded, randomized explorative trial. Participants were randomly assigned (1:1) to receive single-fraction SBRT (24 Gy) or 3DCRT (30 Gy in 10 fractions). The primary endpoint was pain relief of >2 points on the visual analog scale (VAS) measured within the irradiated region at 3 months following radiotherapy completion. Other recorded parameters included pain response (per International Bone Consensus response definitions), use of concurrent medications and opioid usage (oral morphine equivalent dose, OMED). All parameters were assessed at baseline and at three and six months after RT. Intention-to-treat analysis was applied. This trial is registered with ClinicalTrials.gov, number NCT02358720.
Findings: Despite no significant differences for VAS at 3 months between groups (p = 0.13), pain values decreased faster within this time period in the SBRT arm (p = 0.01). At 6 months following RT, significantly lower VAS values were reported in the SBRT group (p = 0.002). There were no differences in OMED consumption at 3 (p = 0.761) and 6 months (p = 0.174). There was a trend toward improved pain response in the SBRT arm at 3 months (p = 0.057), but significantly so after 6 months (p = 0.003). No patient in the SBRT group experienced grade =3 toxicities according to the Common Terminology Criteria for Adverse Events v.4.03.
Conclusions: This randomized trial demonstrates the utility of palliative SBRT for spinal metastases, which was associated with a quicker and improved pain response. Larger ongoing randomized studies will assist in further addressing these endpoints.

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