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THERAPEUTIQUE MEDICAMENTEUSE

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Early palliative care of non-small cell lung cancer in the context of immunotherapy

PIENIAZEK, Malgorzata ; PAWLAK, Piotr ; RADECKA, Barbara
Oncology letters, 12/2020, vol.20, n°6, p. 1-11

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Melatonin to prevent delirium in patients with advanced cancer - a double blind, parallel, randomized, controlled, feasibility trial

LAWLOR, Peter G. ; MCNAMARA-KILIAN, Marie T. ; MACDONALD, Alistair R. ; MOMOLI, Franco ; TIERNEY, Sallyanne ; LACAZE-MASMONTEIL, Nathalie ; DASGUPTA, Monidipa ; AGAR, Meera ; PEREIRA, Jose L. ; CURROW, David ; BUSH, Shirley H.
BMC palliative care, 21/10/2020, vol.19, n°1, p. 1-17

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Simple HPLC-UV method for the quantification of bupivacaine in human plasma with one step protein precipitation

BEN-SAGHROUNE, Hayat ; SBAI, Hicham ; ABDESSADEK, Mohammed ; EL ATTARI, Ahmed ; ACHOUR, Sanae ; EL BOUAZZAOUI, Abderrahim ; KANJAA, Nabil
MEDECINE PALLIATIVE, 06/2020, vol.19, n°3, p. 126-133

Principales thérapeutiques en soins palliatifs chez l'adulte et la personne âgée - médicaments, dispositifs médicaux, prescriptions de sortie

BARBARET, Cécile ; LIATARD-PIERREL, Karine ; MONIER, Pierre-Antoine
Sauramps médical , 09/2020 , 360 p.

Nalbuphine #381

MATHAI, Fay ; PORTUGAL, Frank ; MEHTA, Zankhana ; DAVIS, Mellar P.
JOURNAL OF PALLIATIVE MEDICINE, 11/2019, vol.22, n°11, p. 1473-1474

Supporting patient access to medicines in community palliative care - on-line survey of health professionals' practice, perceived effectiveness and influencing factors

LATTER, Sue ; CAMPLING, Natasha ; BIRTWISTLE, Jacqueline ; RICHARDSON, Alison ; BENNETT, Michael I. ; EWINGS, Sean ; MEADS, David ; SANTER, Miriam
BMC palliative care, 24/09/2020, vol.19, n°1, p. 1-9

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Safety and effectiveness of antipsychotic medication for delirium in patients with advanced cancer - a large-scale multicenter prospective observational study in real-world palliative care settings

MAEDA, Isseki ; OGAWA, Asao ; YOSHIUCHI, Kazuhiro ; AKECHI, Tatsuo ; MORITA, Tatsuya ; OYAMADA, Shunsuke ; YAMAGUCHI, Takuhiro ; IMAI, Kengo ; SAKASHITA, Akihiro ; MATSUMOTO, Yoshihisa ; UEMURA, Keiichi ; NAKAHARA, Rika ; IWASE, Satoru ; PHASE-R DELIRIUM STUDY GROUP
General hospital psychiatry, 14/09/2020, vol.67, p. 35-41

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Hospital readmissions in hospice patients - evaluation of medication-related causes for readmission

DEANGELIS, Joanna ; FELTON LOWRY, Maria
The American journal of hospice and palliative care, 16/09/2020, Pagination inconnue

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Education needed to improve antimicrobial use during end-of-life care of older adults with advanced cancer - a cross-sectional survey

DATTA, Rupak ; TOPAL, Jeffrey ; MCMANUS, Dayna ; SANFT, Tara ; DEMBRY, Louise Marie ; MORRISON, Laura J. ; QUAGLIARELLO, Vincent ; JUTHANI-MEHTA, Manisha
PALLIATIVE MEDICINE, 15/09/2020, Pagination inconnue

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Safety and utility of chloroquine/ hydroxychloroquine in palliative care patients

PROMMER, Eric
The American journal of hospice and palliative care, 15/09/2020, Pagination inconnue

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Charting the territory - end-of-life trajectories for children with complex neurological, metabolic and chromosomal conditions

BAO, Danielle ; FEICHTINGER, Leanne ; ANDREWS, Gail ; PAWLIUK, Colleen ; STEELE, Rose ; SIDEN, Harold Hal
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 08/09/2020, p. 1-8

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Potentially inappropriate treatments at the end of life in nursing home residents - findings from the PACE cross-sectional study in 6 European countries

HONINX, Elisabeth ; VAN DEN BLOCK, L. ; PIERS, R. ; VAN KUIJK, S. M. J. ; ONWUTEAKA-PHILIPSEN, B. D. ; PAYNE, S.A. ; SZCZERBINSKA, K. ; GAMBASSI, G. G. ; FINNE-SOVERI, H. ; DELIENS, Luc ; SMETS, T.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 08/09/2020, p. 1-12

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Effect of antipsychotics and non-pharmacotherapy for the management of delirium in people receiving palliative care

LEE, Kar Yee ; TAN, Edwin Chin Kang ; HANRAHAN, Jane R. ; CHIRCOP, Christopher ; MICHAEL, Felicia ; ONG, Jennifer A.
Journal of pain and palliative care pharmacotherapy, 30/07/2020, p. 1-12

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Are common delirium assessment tools appropriate for evaluating delirium at the end of life in cancer patients?

UCHIDA, Megumi ; MORITA, Tatsuya ; AKECHI, Tatsuo ; YOKOMICHI, Naosuke ; SAKASHITA, Akihiro ; HISANAGA, Takayuki ; MATSUI, Takashi ; OGAWA, Asao ; YOSHIUCHI, Kazuhiro ; IWASE, Satoru ; PHASE-R DELIRIUM STUDY GROUP
Psycho-oncology, 31/07/2020, Pagination inconnue

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Therapeutic options for patients with refractory status epilepticus in palliative settings or with a limitation of life-sustaining therapies - a systematic review

WILLEMS, Laurent M. ; BAUER, Sebastian ; JAHNKE, Kolja ; VOSS, Martin ; ROSENOW, Felix ; STRZELCZYK, Adam
CNS drugs, 08/2020, vol.34, n°8, p. 801-826

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Thème : Médicaments - Pharmacie.

REVUE SYSTEMATIQUE ; MALADIE NEUROLOGIQUE ; THERAPEUTIQUE MEDICAMENTEUSE ; DEMARCHE PALLIATIVE

BACKGROUND: Refractory status epilepticus (RSE) represents a serious medical condition requiring early and targeted therapy. Given the increasing number of elderly or multimorbid patients with a limitation of life-sustaining therapy (LOT) or within a palliative care setting (PCS), guidelines-oriented therapy escalation options for RSE have to be omitted frequently.
OBJECTIVES: This systematic review sought to summarize the evidence for fourth-line antiseizure drugs (ASDs) and other minimally or non-invasive therapeutic options beyond guideline recommendations in patients with RSE to elaborate on possible treatment options for patients undergoing LOT or in a PCS.
METHODS: A systematic review of the literature in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, focusing on fourth-line ASDs or other minimally or non-invasive therapeutic options was performed in February and June 2020 using the MEDLINE, EMBASE and Cochrane databases. The search terminology was constructed using the name of the specific ASD or therapy option and the term 'status epilepticus' with the use of Boolean operators, e.g. "(brivaracetam) AND (status epilepticus)". The respective Medical Subject Headings (MeSH) and Emtree terms were used, if available.
RESULTS: There is currently no level 1, grade A evidence for the use of ASDs in RSE. The best evidence was found for the use of lacosamide and topiramate (level 3, grade C), followed by brivaracetam, perampanel (each level 4, grade D) and stiripentol, oxcarbazepine and zonisamide (each level 5, grade D). Regarding non-medicinal options, there is little evidence for the use of the ketogenic diet (level 4, grade D) and magnesium sulfate (level 5, grade D) in RSE. The broad use of immunomodulatory or immunosuppressive treatment options in the absence of a presumed autoimmune etiology cannot be recommended; however, if an autoimmune etiology is assumed, steroid pulse, intravenous immunoglobulins and plasma exchange/plasmapheresis should be considered (level 4, grade D). Even if several studies suggested that the use of neurosteroids (level 5, grade D) is beneficial in RSE, the current data situation indicates that there is formal evidence against it.
CONCLUSIONS: RSE in patients undergoing LOT or in a PCS represents a challenge for modern clinicians and epileptologists. The evidence for the use of ASDs in RSE beyond that in current guidelines is low, but several effective and well-tolerated options are available that should be considered in this patient population. More so than in any other population, advance care planning, advance directives, and medical ethical aspects have to be considered carefully before and during therapy.

Origine : PubMed

Medication use in the last year of life - a cross-sectional hospice study

SCULLION, Liam ; DODDS, Hope ; LIU, Qinghao ; HUNT, Mary Elizabeth ; GORDON, Simon ; TODD, Adam
BMJ supportive and palliative care, 11/08/2020, Pagination inconnue

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A retrospective study analyzing the lack of symptom benefit with antimicrobials at the end of life

LOPEZ, Santiago ; VYAS, Pooja ; MALHOTRA, Prashant ; FINUF, Kayla ; MAGALEE, Christopher ; NOURYAN, Christian ; HIRSCH, Bruce
The American journal of hospice and palliative care, 24/08/2020, Pagination inconnue

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Pain management during the withholding and withdrawal of life support in critically ill patients at the end-of-life - a systematic review and meta-analysis

LASERNA, Andres ; DURAN-CRANE, Alejandro ; LOPEZ-OLIVO, Maria A. ; CUENCA, John A. ; FOWLER, Cosmo ; DIAZ DIEZ, Diana Paola ; CARDENAS, Yenny R. ; URSO, Catherine ; O'CONNELL, Keara ; FOWLER, Clara ; PRICE, Kristen J. ; SPRUNG, Charles L. ; NATES, Joseph L.
Intensive care medicine, 24/08/2020, p. 1671-1682

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Palliative care during covid-19 - data and visits from loved ones

HEATH, Laura ; YATES, Sharon ; CAREY, Matthew ; MILLER, Mary G.
The American journal of hospice and palliative care, 11/2020, vol.37, n°11, p. 988-991

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Polypharmacy, medication possession, and deprescribing of potentially non-beneficial drugs in hospice patients

DUNCAN, Ian ; MAXWELL, Terri L. ; HUYNH, Nhan ; TODD, Marisa
The American journal of hospice and palliative care, 12/2020, vol.37, n°12, p. 1076-1085

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