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THERAPEUTIQUE MEDICAMENTEUSE

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Development and validation of a uremic pruritus treatment algorithm and patient information toolkit in patients with chronic kidney disease and end stage kidney disease

RAGAZZO, Jessica ; CESTA, Annemarie ; JASSAL, Vanita ; CHIANG, Nicholas ; BATTISTELLA, Marisa
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 02/2020, vol.59, n°2, p. 279-292

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Patterns of symptom management medication receipt at end-of-life among Medicare beneficiaries with lung cancer

SAPHIRE, Maureen L. ; PRSIC, Elizabeth H. ; CANAVAN, Maureen E. ; WANG, Shi-Yi J. ; PRESLEY, Carolyn J. ; DAVIDOFF, Amy J.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 04/2020, vol.59, n°4, p. 767-777

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Factors affecting access to subcutaneous medicines for people dying in the community

TAIT, Paul ; SHEEHY, Kylee ; SINDHUSAKE, Doungkamol ; MUSCILLO, Nina
PROGRESS IN PALLIATIVE CARE, 06/04/2020, p. 1-8

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Off-label drugs in palliative care - a group Delphi treatment recommendation process

REMI, Constanze ; WEINGARTNER, Kathrin ; HAGEMANN, Vera ; BAUSEWEIN, Claudia ; HODIAMONT, Farina
BMJ supportive and palliative care, 12/05/2020, Pagination inconnue

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Role of nurses in medication management at the end of life - a qualitative interview study

HUISMAN, Bregje A. A. ; GEIJTEMAN, Eric C. T. ; DEES, Marianne K. ; SCHONEWILLE, Noralie N. ; WIELES, Margriet ; VAN ZUYLEN, Lia ; SZADEK, Karolina M. ; VAN DER HEIDE, Agnes
BMC palliative care, 13/05/2020, vol.19, n°1, p. 1-11

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An exploration of the experiences of professionals supporting patients approaching the end of life in medicines management at home - a qualitative study

WILSON, Eleanor ; CASWELL, Glenys ; LATIF, Asam ; ANDERSON, Claire ; FAULL, Christina ; POLLOCK, Kristian
BMC palliative care, 11/05/2020, vol.19, n°1, p. 1-10

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Megestrol for palliative care in patients with cancer

WONG, Meagan ; SISAY, Mariatou ; NEHER, Jon O. ; SAFRANEK, Sarah
American family physician, 01/05/2020, vol.101, n°9, Pagination inconnue

Palliative drug treatments for breathlessness in cystic fibrosis

JAISWAL, Nishant ; SINGH, Meenu ; AGARWAL, Amit ; CHAUHAN, Anil ; JAISWAL, Nikita
The Cochrane database of systematic reviews, 28/04/2020, vol.4, Pagination inconnue

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Thème : Médicaments - Pharmacie.

THERAPEUTIQUE MEDICAMENTEUSE ; MUCOVISCIDOSE ; SYMPTOME RESPIRATOIRE ; REVUE SYSTEMATIQUE

BACKGROUND: Cystic fibrosis is a life-limiting autosomal recessive genetic illness. A feeling of shortness of breath is common in cystic fibrosis, especially as the disease progresses. Reversing the underlying cause is the priority when treating breathlessness (dyspnoea), but when it is not feasible, palliation (easing) becomes the primary goal to improve an individual's quality of life. A range of drugs administered by various routes have been used, but no definite guidelines are available. A systematic review is needed to evaluate such treatments.
OBJECTIVES: To assess the efficacy and safety of drugs used to ease breathlessness in people with cystic fibrosis.
SEARCH METHODS: We searched the Cochrane Cystic Fibrosis Trials Register, compiled from electronic database searches and handsearching of journals and conference abstract books. Date of last search: 18 November 2019. We searched databases (clinicaltrials.gov, the ISRCTN registry, the Clinical Trials Registry India and WHO ICTRP) for ongoing trials. These searches were last run on 06 March 2020.
SELECTION CRITERIA: We planned to include randomised and quasi-randomised controlled trials in people with cystic fibrosis (diagnosed by a positive sweat chloride test or genetic testing) who have breathlessness. We considered studies comparing any drugs used for easing breathlessness to another drug administered by any route (inhaled (nebulised), intravenous, oral, subcutaneous, transmucosal (including buccal, sublingual and intra-nasal) and transdermal).
DATA COLLECTION AND ANALYSIS: The authors assessed the search results according to the pre-defined inclusion criteria.
MAIN RESULTS: The new searches in 2020 yielded two ongoing studies that were not relevant to the review question. Previous searches had found only one study (cross-over in design), which did not fulfil the inclusion criteria as no data were available from the first treatment period alone.
AUTHORS' CONCLUSIONS: Due to the lack of available evidence, this review cannot provide any information for clinical practice. The authors call for specific research in this area after taking into account relevant ethical considerations. The research should focus on the efficacy and safety of the drugs with efficacy being measured in terms of improvement in quality of life, dyspnoea scores and hospital stay.

Origine : PubMed

Administration of end-of-life drugs by family caregivers during Covid-19 pandemic

BOWERS, Ben ; POLLOCK, Kristian ; BARCLAY, Stephen
BMJ, 24/04/2020, vol.369, p. 1-2

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Prescribing medications of questionable benefit prior to death - a retrospective study on older nursing home residents with and without dementia in Germany

RAUSCH, Christian ; HOFFMANN, Falk
European journal of clinical pharmacology, 26/03/2020, p. 1-9

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Inappropriate medications among end-of-life patients living at home - an Italian observational study

PASINA, Luca ; RECCHIA, Angela ; NOBILI, Alessandro ; RIZZI, Barbara
European geriatric medicine, 06/04/2020, Pagination inconnue

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Medication use in aged care residents in the last year of life - a scoping review

AITKEN, Charlotte ; BOYD, Michal ; NIELSEN, Lorraine ; COLLIER, Aileen
PALLIATIVE MEDICINE, 14/04/2020, Pagination inconnue

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Palliative care symptoms, outcomes, and interventions for chronic advanced patients in Spanish nursing homes with and without dementia

PUENTE-FERNANDEZ, Daniel ; CAMPOS-CALDERON, Concepcion Petra ; BURGOS, Ana Alejandra Esteban ; HUESO-MONTORO, César ; ROLDAN-LOPEZ, Concepcion Beatriz ; MONTOYA-JUAREZ, Rafael
International journal of environmental research and public health, 25/02/2020, vol.17, n°5, p. 1-12

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What are the factors identifying caregivers who need help in managing medications for palliative care patients at home? - a population survey

TAIT, Paul ; CUTHBERTSON, Elizabeth ; CURROW, David
JOURNAL OF PALLIATIVE MEDICINE, 10/03/2020, Pagination inconnue

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Polypharmacy, inappropriate medication use, and drug interactions in older Korean patients with cancer receiving first-line palliative chemotherapy

HONG, Soojung ; LEE, Ju Hyun ; CHUN, Eun Kyeong ; KIM, Kwang-Il ; KIM, Jin Won ; KIM, Se Hyun ; LEE, Yun-Gyoo ; HWANG, In Gyu ; KIM, Jin Young ; KOH, Su-Jin ; KO, Yoon Ho ; SHIN, Seong Hoon ; WOO, In Sook ; KIM, Tae-Yong ; BAEK, Ji Yeon ; KIM, Hyun Jung ; KIM, Hyo Jung ; LEE, Myung Ah ; KWON, Jung Hye ; HONG, Yong Sang ; RYOO, Hun-Mo ; KIM, Jee Hyun
The oncologist, 03/2020, vol.25, n°3, p. e502-e511

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Prospective evaluation of intensity of symptoms, therapeutic procedures and treatment in palliative care patients in nursing homes

PUENTE-FERNANDEZ, Daniel ; ROLDAN-LOPEZ, Concepción B. ; CAMPOS-CALDERON, Concepción P. ; HUESO-MONTORO, Cesar ; GARCIA-CARO, María P. ; MONTOYA-JUAREZ, Rafael
Journal of clinical medicine, 10/03/2020, vol.9, n°3, p. 1-11

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Prevalent statin use in long-stay nursing home residents with life-limiting illness

MACK, Deborah S. ; TJIA, Jennifer ; HUME, Anne L. ; LAPANE, Kate L.
Journal of the American Geriatrics Society, 14/02/2020, Pagination inconnue

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Thème : Médicaments - Pharmacie.

THERAPEUTIQUE MEDICAMENTEUSE ; PREVALENCE ; MAISON RETRAITE ; MALADIE LETALE ; ETATS-UNIS

OBJECTIVES; To evaluate the prevalence and factors associated with statin pharmacotherapy in long-stay nursing home residents with life-limiting illness.
DESIGN: Cross-sectional.
SETTING: US Medicare- and Medicaid-certified nursing home facilities.
PARTICIPANTS: Long-stay nursing home resident Medicare fee-for-service beneficiaries aged 65 years or older with life-limiting illness (n = 424 212).
MEASUREMENTS: Prevalent statin use was estimated as any low-moderate intensity (daily dose low-density lipoprotein-cholesterol [LDL-C] reduction <30%-50%) and high-intensity (daily dose LDL-C reduction >50%) use via Medicare Part D claims for a prescription supply on September 30, 2016, with a 90-day look-back period. Life-limiting illness was operationally defined to capture those near the end of life using evidence-based criteria to identify progressive terminal conditions or limited prognoses (<6 mo). Poisson models provided estimates of adjusted prevalence ratios and 95% confidence intervals for resident factors.
RESULTS: A total of 34% of residents with life-limiting illness were prescribed statins (65--75 y = 44.0%, high intensity = 11.1%; >75 y = 31.1%, high intensity = 5.4%). Prevalence of statins varied by life-limiting illness definition. Of those with a prognosis of less than 6 months, 23% of the 65 to 75 and 12% of the older than 75 age groups were on statins. Factors positively associated with statin use included minority race or ethnicity, use of more than five concurrent medications, and atherosclerotic cardiovascular disease or risk factors.
CONCLUSION: Despite having a life-limiting illness, more than one-third of clinically compromised long-stay nursing home residents remain on statins. Although recent national guidelines have expanded indications for statins, the benefit of continued therapy in an advanced age population near the end of life is questionable. Efforts to deprescribe statins in the nursing home setting may be warranted.

Origine : PubMed

Incidence and predictors of aspirin discontinuation in older adult veteran nursing home residents at end of life

SPRINGER, Sydney P. ; MOR, Maria K. ; SILEANU, Florentina ; ZHAO, Xinhua ; ASPINALL, Sherrie L. ; ERSEK, Mary ; NIZNIK, Joshua D. ; HANLON, Joseph T. ; HUNNICUTT, Jacob ; GELLAD, Walid F. ; SCHLEIDEN, Loren J. ; THORPE, Joshua M. ; THORPE, Carolyn T.
Journal of the American Geriatrics Society, 13/02/2020, Pagination inconnue

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Deintensification of diabetes medications among veterans at the end of life in VA nursing homes

NIZNIK, Joshua D. ; HUNNICUTT, Jacob N. ; ZHAO, Xinhua ; MOR, Maria K. ; SILEANU, Florentina ; ASPINALL, Sherrie L. ; SPRINGER, Sydney P. ; ERSEK, Mary J. ; GELLAD, Walid F. ; SCHLEIDEN, Loren J. ; HANLON, Joseph T. ; THORPE, Joshua M. ; THORPE, Carolyn T.
Journal of the American Geriatrics Society, 17/02/2020, Pagination inconnue

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Characteristics of hospitalized patients screening positive for delirium

NGUYEN, Trinh H. ; ATAYEE, Rabia S. ; DERRY, Katrina L. ; HIRST, Jeremy ; BIONDO, Anthony ; EDMONDS, Kyle P.
The American journal of hospice and palliative care, 02/2020, vol.37, n°2, p. 142-148

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